Novel bilayer microarray patch-assisted long-acting micro-depot cabotegravir intradermal delivery for HIV pre-exposure prophylaxis

Ismaiel A. Tekko; Lalitkumar K. Vora; Fabiana Volpe-Zanutto; Kurtis Moffatt; Courtney Jarrahian; Helen O. McCarthy; Ryan F. Donnelly

doi:10.1002/adfm.202106999

Novel bilayer microarray patch-assisted long-acting micro-depot cabotegravir intradermal delivery for HIV pre-exposure prophylaxis

Ismaiel A. Tekko, Lalitkumar K. Vora, Fabiana Volpe-Zanutto, Kurtis Moffatt, Courtney Jarrahian, Helen O. McCarthy, Ryan F. Donnelly

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

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Abstract

Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited, especially in low-income countries (LICs). Herein, for the first time, the development of a bilayer microarray patch (MAP) with unique design and novel formulation as a potential alternative self-administrated intradermal delivery system for CAB is reported. The novel MAP has a high drug load (≈3 mg/0.5 cm2 of CAB LA or its micronized sodium salt) and fast-dissolving tips (

Original language	English
Article number	2106999
Pages (from-to)	1-18
Number of pages	18
Journal	Advanced Functional Materials
Volume	32
Issue number	9
DOIs	https://doi.org/10.1002/adfm.202106999
Publication status	Published (in print/issue) - 23 Feb 2022

Keywords

Biomaterials
Condensed Matter Physics
Electrochemistry
Electronic
Optical and Magnetic Materials

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10.1002/adfm.202106999

Adv Funct Materials - 2021 - Tekko - Novel Bilayer Microarray Patch‐Assisted Long‐Acting Micro‐Depot Cabotegravir (2)Final published version, 9.46 MBLicence: CC BY

Cite this

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title = "Novel bilayer microarray patch-assisted long-acting micro-depot cabotegravir intradermal delivery for HIV pre-exposure prophylaxis",

abstract = "Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited, especially in low-income countries (LICs). Herein, for the first time, the development of a bilayer microarray patch (MAP) with unique design and novel formulation as a potential alternative self-administrated intradermal delivery system for CAB is reported. The novel MAP has a high drug load (≈3 mg/0.5 cm2 of CAB LA or its micronized sodium salt) and fast-dissolving tips (",

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AU - Tekko, Ismaiel A.

AU - Vora, Lalitkumar K.

AU - Volpe-Zanutto, Fabiana

AU - Moffatt, Kurtis

AU - Jarrahian, Courtney

AU - McCarthy, Helen O.

AU - Donnelly, Ryan F.

PY - 2022/2/23

Y1 - 2022/2/23

N2 - Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited, especially in low-income countries (LICs). Herein, for the first time, the development of a bilayer microarray patch (MAP) with unique design and novel formulation as a potential alternative self-administrated intradermal delivery system for CAB is reported. The novel MAP has a high drug load (≈3 mg/0.5 cm2 of CAB LA or its micronized sodium salt) and fast-dissolving tips (

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KW - Biomaterials

KW - Condensed Matter Physics

KW - Electrochemistry

KW - Electronic

KW - Optical and Magnetic Materials

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Novel bilayer microarray patch-assisted long-acting micro-depot cabotegravir intradermal delivery for HIV pre-exposure prophylaxis

Abstract

Keywords

UN SDGs

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