Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions

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Abstract

The pancreas has physiologically important endocrine and exocrine functions; secreting enzymes into the small intestine to aid digestion and releasing multiple peptide hormones via the islets of Langerhans to regulate glucose metabolism, respectively. Insulin and glucagon, in combination with ghrelin, pancreatic polypeptide and somatostatin, are the main classical islet peptides critical for the maintenance of blood glucose. However, pancreatic islets also synthesis numerous 'nonclassical' peptides that have recently been demonstrated to exert fundamental effects on overall islet function and metabolism. As such, insights into the physiological relevance of these nonclassical peptides have shown impact on glucose metabolism, insulin action, cell survival, weight loss, and energy expenditure. This review will focus on the role of individual nonclassical islet peptides to stimulate pancreatic islet secretions as well as regulate metabolism. In addition, the more recognised actions of these peptides on satiety and energy regulation will also be considered. Furthermore, recent advances in the field of peptide therapeutics and obesity-diabetes have focused on the benefits of simultaneously targeting several hormone receptor signalling cascades. The potential for nonclassical islet hormones within such combinational approaches will also be discussed.
Original languageEnglish
Article number1179551419888871
Pages (from-to)1-10
JournalClinical Medicine Insights: Endocrinology and Diabetes
Volume12
Early online date12 Dec 2019
DOIs
Publication statusE-pub ahead of print - 12 Dec 2019

Keywords

  • dual agonist
  • insulin secretion
  • nonclassical islet peptides
  • triagonist
  • beta cell

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