No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study

Maud Andriollo-Sanchez, Isabelle Hininger-Favier, Nathalie Meunier, Eugenia Venneria, JM O'Connor, Giuseppe Maiani, Angela Polito, Severine Bord, Monique Ferry, Charles Coudray, Anne-Marie Roussel

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control. Setting: France (Clermont-Ferrand/Theix. and Grenoble), Italy (Rome), Northern Ireland (Coleraine). Subjects: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly. after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.
LanguageEnglish
Pages463-469
JournalJournal of the American College of Nutrition
Volume27
Issue number4
Publication statusPublished - Aug 2008

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Zinc
Oxidative Stress
Antioxidants
Northern Ireland
Sulfhydryl Compounds
Italy
Lipid Peroxidation
Superoxide Dismutase
France
Glutathione
Blood Proteins
Copper
Erythrocytes
Placebos
Prospective Studies

Cite this

Andriollo-Sanchez, M., Hininger-Favier, I., Meunier, N., Venneria, E., O'Connor, JM., Maiani, G., ... Roussel, A-M. (2008). No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study. Journal of the American College of Nutrition, 27(4), 463-469.
Andriollo-Sanchez, Maud ; Hininger-Favier, Isabelle ; Meunier, Nathalie ; Venneria, Eugenia ; O'Connor, JM ; Maiani, Giuseppe ; Polito, Angela ; Bord, Severine ; Ferry, Monique ; Coudray, Charles ; Roussel, Anne-Marie. / No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study. In: Journal of the American College of Nutrition. 2008 ; Vol. 27, No. 4. pp. 463-469.
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abstract = "Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control. Setting: France (Clermont-Ferrand/Theix. and Grenoble), Italy (Rome), Northern Ireland (Coleraine). Subjects: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly. after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.",
author = "Maud Andriollo-Sanchez and Isabelle Hininger-Favier and Nathalie Meunier and Eugenia Venneria and JM O'Connor and Giuseppe Maiani and Angela Polito and Severine Bord and Monique Ferry and Charles Coudray and Anne-Marie Roussel",
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Andriollo-Sanchez, M, Hininger-Favier, I, Meunier, N, Venneria, E, O'Connor, JM, Maiani, G, Polito, A, Bord, S, Ferry, M, Coudray, C & Roussel, A-M 2008, 'No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study', Journal of the American College of Nutrition, vol. 27, no. 4, pp. 463-469.

No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study. / Andriollo-Sanchez, Maud; Hininger-Favier, Isabelle; Meunier, Nathalie; Venneria, Eugenia; O'Connor, JM; Maiani, Giuseppe; Polito, Angela; Bord, Severine; Ferry, Monique; Coudray, Charles; Roussel, Anne-Marie.

In: Journal of the American College of Nutrition, Vol. 27, No. 4, 08.2008, p. 463-469.

Research output: Contribution to journalArticle

TY - JOUR

T1 - No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study

AU - Andriollo-Sanchez, Maud

AU - Hininger-Favier, Isabelle

AU - Meunier, Nathalie

AU - Venneria, Eugenia

AU - O'Connor, JM

AU - Maiani, Giuseppe

AU - Polito, Angela

AU - Bord, Severine

AU - Ferry, Monique

AU - Coudray, Charles

AU - Roussel, Anne-Marie

PY - 2008/8

Y1 - 2008/8

N2 - Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control. Setting: France (Clermont-Ferrand/Theix. and Grenoble), Italy (Rome), Northern Ireland (Coleraine). Subjects: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly. after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.

AB - Objective: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. Design: Multicentre prospective intervention study, randomized, double-blind, placebo-control. Setting: France (Clermont-Ferrand/Theix. and Grenoble), Italy (Rome), Northern Ireland (Coleraine). Subjects: A total of 387 healthy middle-aged (55-70 yrs) and free-living older aged (70-85 yrs) subjects were randomly allocated to three groups: 0, 15 or 30 mg zinc gluconate/d in addition to usual dietary intake during 6 months. Methods: Oxidative stress status was evaluated by measurement of protein oxidation (plasma thiol groups), lipid peroxidation (plasma thio-barbituric acid reactants, TBARS), whole blood glutathione levels, erythrocyte copper/zinc superoxide dismutase activity and plasma antioxidant status (ferric reducing antioxidant power assay), at baseline and after 3 and 6 months. Results: Zinc supplementation did not alter oxidative stress markers and antioxidant defenses in elderly. after 3 or 6 months, except an increase in Cu/Zn superoxide dismutase activity. Conclusions: In apparently healthy free living elderly people, a single zinc supplementation had no effects on oxidative stress status.

M3 - Article

VL - 27

SP - 463

EP - 469

JO - Journal of the American College of Nutrition

T2 - Journal of the American College of Nutrition

JF - Journal of the American College of Nutrition

SN - 0731-5724

IS - 4

ER -