NLRP3 as a potentially novel biomarker for the management of osteoarthritis

Megan McAllister; Melody El Chemaly; Amanda J Eakin; David S Gibson; Victoria E McGilligan

doi:10.1016/j.joca.2018.02.901

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

Megan McAllister
, Melody El Chemaly
, Amanda J Eakin
, David S Gibson
, Victoria E McGilligan

Invest NI

Research output: Contribution to journal › Article › peer-review

188 Citations (Scopus)

98 Downloads (Pure)

Abstract

Osteoarthritis was previously thought of as ‘wear and tear’ as humans age, however there is increasing evidence to support an inflammatory theory. The NLRP3 inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as IL-1β, TNF-α and MMP-3 which drive cartilage degeneration and synovial inflammation. This review aims to summarise the evidence of NLRP3 involvement in osteoarthritis. Currently, treatment options focus on management of the disease and to date there is no cure. The development of novel biomarkers for osteoarthritis could improve diagnosis, treatment and management. Importantly, this review provides detail on the involvement of the NLRP3 inflammasome in osteoarthritis pathology and how its members could act as potential biomarkers to assist clinical decisions.

Original language	English
Pages (from-to)	612–619
Number of pages	8
Journal	Osteoarthritis and Cartilage
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.joca.2018.02.901
Publication status	Published (in print/issue) - 31 May 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Osteoarthritis
NLRP3
inflammasome
biomarker
inflammation

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10.1016/j.joca.2018.02.901

MMcA Manuscript Clean Copy 060218Author Accepted Manuscript, 41.8 KB

https://doi.org/10.1016/j.joca.2018.02.901

Investigating known and novel biomarkers for risk stratification in cardiovascular disease
Chemaly, M. (Author), McGilligan, V. (Supervisor), Bjourson, A. (Supervisor) & Peace, A. (Supervisor), May 2018
Student thesis: Doctoral Thesis

File

Cite this

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title = "NLRP3 as a potentially novel biomarker for the management of osteoarthritis",

abstract = "Osteoarthritis was previously thought of as {\textquoteleft}wear and tear{\textquoteright} as humans age, however there is increasing evidence to support an inflammatory theory. The NLRP3 inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as IL-1β, TNF-α and MMP-3 which drive cartilage degeneration and synovial inflammation. This review aims to summarise the evidence of NLRP3 involvement in osteoarthritis. Currently, treatment options focus on management of the disease and to date there is no cure. The development of novel biomarkers for osteoarthritis could improve diagnosis, treatment and management. Importantly, this review provides detail on the involvement of the NLRP3 inflammasome in osteoarthritis pathology and how its members could act as potential biomarkers to assist clinical decisions.",

keywords = "Osteoarthritis, NLRP3, inflammasome, biomarker, inflammation",

author = "Megan McAllister and \{El Chemaly\}, Melody and Eakin, \{Amanda J\} and Gibson, \{David S\} and McGilligan, \{Victoria E\}",

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doi = "10.1016/j.joca.2018.02.901",

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AU - McAllister, Megan

AU - El Chemaly, Melody

AU - Eakin, Amanda J

AU - Gibson, David S

AU - McGilligan, Victoria E

PY - 2018/5/31

Y1 - 2018/5/31

N2 - Osteoarthritis was previously thought of as ‘wear and tear’ as humans age, however there is increasing evidence to support an inflammatory theory. The NLRP3 inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as IL-1β, TNF-α and MMP-3 which drive cartilage degeneration and synovial inflammation. This review aims to summarise the evidence of NLRP3 involvement in osteoarthritis. Currently, treatment options focus on management of the disease and to date there is no cure. The development of novel biomarkers for osteoarthritis could improve diagnosis, treatment and management. Importantly, this review provides detail on the involvement of the NLRP3 inflammasome in osteoarthritis pathology and how its members could act as potential biomarkers to assist clinical decisions.

AB - Osteoarthritis was previously thought of as ‘wear and tear’ as humans age, however there is increasing evidence to support an inflammatory theory. The NLRP3 inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as IL-1β, TNF-α and MMP-3 which drive cartilage degeneration and synovial inflammation. This review aims to summarise the evidence of NLRP3 involvement in osteoarthritis. Currently, treatment options focus on management of the disease and to date there is no cure. The development of novel biomarkers for osteoarthritis could improve diagnosis, treatment and management. Importantly, this review provides detail on the involvement of the NLRP3 inflammasome in osteoarthritis pathology and how its members could act as potential biomarkers to assist clinical decisions.

KW - Osteoarthritis

KW - NLRP3

KW - inflammasome

KW - biomarker

KW - inflammation

U2 - 10.1016/j.joca.2018.02.901

DO - 10.1016/j.joca.2018.02.901

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JO - Osteoarthritis and Cartilage

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ER -

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

Abstract

UN SDGs

Keywords

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Student theses

Investigating known and novel biomarkers for risk stratification in cardiovascular disease

Cite this