New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease?

Christian Holscher, Lin Li

    Research output: Contribution to journalArticle

    Abstract

    Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD). This is most likely due to the desensitisation of insulin receptors in the brain. Insulin acts as a growth factor and supports neuronal repair, dendritic sprouting, and differentiation. This review discusses the potential role that insulin-like hormones could play in ameliorating the reduced growth factor signalling in the brains of people with AD. The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have very similar properties in protecting neurons from toxic effects, and are capable of reversing the detrimental effects that beta-amyloid fragments have on synaptic plasticity. Therefore, incretins show great promise as a novel treatment for reducing degenerative processes in AD
    LanguageEnglish
    Pages1495-1502
    JournalNeurobiology of Aging
    Volume31
    Issue number9
    Early online date18 Oct 2008
    DOIs
    Publication statusPublished - Sep 2010

    Fingerprint

    Hope
    Incretins
    Alzheimer Disease
    Hormones
    Insulin
    Intercellular Signaling Peptides and Proteins
    Neuronal Plasticity
    Glucagon-Like Peptide 1
    Poisons
    Insulin Receptor
    Brain
    Amyloid
    Type 2 Diabetes Mellitus
    Neurons
    Glucose
    Peptides
    Neuroprotection

    Cite this

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    abstract = "Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD). This is most likely due to the desensitisation of insulin receptors in the brain. Insulin acts as a growth factor and supports neuronal repair, dendritic sprouting, and differentiation. This review discusses the potential role that insulin-like hormones could play in ameliorating the reduced growth factor signalling in the brains of people with AD. The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have very similar properties in protecting neurons from toxic effects, and are capable of reversing the detrimental effects that beta-amyloid fragments have on synaptic plasticity. Therefore, incretins show great promise as a novel treatment for reducing degenerative processes in AD",
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    New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease? / Holscher, Christian; Li, Lin.

    In: Neurobiology of Aging, Vol. 31, No. 9, 09.2010, p. 1495-1502.

    Research output: Contribution to journalArticle

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