New models of atherosclerosis and multi-drug therapeutic interventions.

Andrew Parton; V. E. McGilligan; Melody El Chemaly; Maurice O'Kane; Steven Watterson

doi:10.1093/bioinformatics/bty980

New models of atherosclerosis and multi-drug therapeutic interventions.

Andrew Parton
, V. E. McGilligan
, Melody El Chemaly
, Maurice O'Kane
, Steven Watterson

Western Health & Social Care Trust

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

107 Downloads (Pure)

Abstract

Motivation. Atherosclerosis is amongst the leading causes of death globally. However, it is challenging to study in vivo or in vitro and no detailed, openly-available computational models exist. Clinical studies hint that pharmaceutical therapy may be possible. Here we develop the first detailed, computational model of atherosclerosis and use it to develop multi-drug therapeutic hypotheses.

Results. We assembled a network describing atheroma development from the literature. Maps and mathematical models were produced using the Systems Biology Graphical Notation (SBGN) and Systems Biology Markup Language (SBML), respectively. The model was constrained against clinical and laboratory data. We identified five drugs that together potentially reverse advanced atheroma formation.

Availability and Implementation. The map is available in the supplementary information in SBGN-ML format. The model is available in the supplementary material and from BioModels, a repository of SBML models, containing CellDesigner markup.

Supplementary Information. Available from Bioinformatics online.

Original language	English
Pages (from-to)	2449-2457
Number of pages	9
Journal	Bioinformatics
Volume	35
Issue number	14
Early online date	6 Dec 2018
DOIs	https://doi.org/10.1093/bioinformatics/bty980
Publication status	Published (in print/issue) - 31 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Systems biology
Atherosclerosis
Cardiovascular
pathways

Access to Document

10.1093/bioinformatics/bty980

Accepted manuscriptAuthor Accepted Manuscript, 3.44 MB

Cite this

@article{1452f5815cdb4b65afa25bb48c8bcc4b,

title = "New models of atherosclerosis and multi-drug therapeutic interventions.",

abstract = "Motivation. Atherosclerosis is amongst the leading causes of death globally. However, it is challenging to study in vivo or in vitro and no detailed, openly-available computational models exist. Clinical studies hint that pharmaceutical therapy may be possible. Here we develop the first detailed, computational model of atherosclerosis and use it to develop multi-drug therapeutic hypotheses. Results. We assembled a network describing atheroma development from the literature. Maps and mathematical models were produced using the Systems Biology Graphical Notation (SBGN) and Systems Biology Markup Language (SBML), respectively. The model was constrained against clinical and laboratory data. We identified five drugs that together potentially reverse advanced atheroma formation. Availability and Implementation. The map is available in the supplementary information in SBGN-ML format. The model is available in the supplementary material and from BioModels, a repository of SBML models, containing CellDesigner markup. Supplementary Information. Available from Bioinformatics online.",

keywords = "Systems biology, Atherosclerosis, Cardiovascular, pathways",

author = "Andrew Parton and McGilligan, \{V. E.\} and \{El Chemaly\}, Melody and Maurice O'Kane and Steven Watterson",

year = "2019",

month = jul,

day = "31",

doi = "10.1093/bioinformatics/bty980",

language = "English",

volume = "35",

pages = "2449--2457",

journal = "Bioinformatics",

issn = "1367-4803",

publisher = "Oxford University Press",

number = "14",

}

TY - JOUR

T1 - New models of atherosclerosis and multi-drug therapeutic interventions.

AU - Parton, Andrew

AU - McGilligan, V. E.

AU - El Chemaly, Melody

AU - O'Kane, Maurice

AU - Watterson, Steven

PY - 2019/7/31

Y1 - 2019/7/31

N2 - Motivation. Atherosclerosis is amongst the leading causes of death globally. However, it is challenging to study in vivo or in vitro and no detailed, openly-available computational models exist. Clinical studies hint that pharmaceutical therapy may be possible. Here we develop the first detailed, computational model of atherosclerosis and use it to develop multi-drug therapeutic hypotheses. Results. We assembled a network describing atheroma development from the literature. Maps and mathematical models were produced using the Systems Biology Graphical Notation (SBGN) and Systems Biology Markup Language (SBML), respectively. The model was constrained against clinical and laboratory data. We identified five drugs that together potentially reverse advanced atheroma formation. Availability and Implementation. The map is available in the supplementary information in SBGN-ML format. The model is available in the supplementary material and from BioModels, a repository of SBML models, containing CellDesigner markup. Supplementary Information. Available from Bioinformatics online.

AB - Motivation. Atherosclerosis is amongst the leading causes of death globally. However, it is challenging to study in vivo or in vitro and no detailed, openly-available computational models exist. Clinical studies hint that pharmaceutical therapy may be possible. Here we develop the first detailed, computational model of atherosclerosis and use it to develop multi-drug therapeutic hypotheses. Results. We assembled a network describing atheroma development from the literature. Maps and mathematical models were produced using the Systems Biology Graphical Notation (SBGN) and Systems Biology Markup Language (SBML), respectively. The model was constrained against clinical and laboratory data. We identified five drugs that together potentially reverse advanced atheroma formation. Availability and Implementation. The map is available in the supplementary information in SBGN-ML format. The model is available in the supplementary material and from BioModels, a repository of SBML models, containing CellDesigner markup. Supplementary Information. Available from Bioinformatics online.

KW - Systems biology

KW - Atherosclerosis

KW - Cardiovascular

KW - pathways

UR - https://pure.ulster.ac.uk/en/publications/new-models-of-atherosclerosis-and-multi-drug-therapeutic-interven

U2 - 10.1093/bioinformatics/bty980

DO - 10.1093/bioinformatics/bty980

M3 - Article

C2 - 30520978

SN - 1367-4803

VL - 35

SP - 2449

EP - 2457

JO - Bioinformatics

JF - Bioinformatics

IS - 14

ER -

New models of atherosclerosis and multi-drug therapeutic interventions.

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Investigating known and novel biomarkers for risk stratification in cardiovascular disease

The dynamics of cholesterol metabolism and atherosclerosis across population subgroups

Steven Watterson

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New models of atherosclerosis and multi-drug therapeutic interventions.

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Investigating known and novel biomarkers for risk stratification in cardiovascular disease

The dynamics of cholesterol metabolism and atherosclerosis across population subgroups

Profiles

Steven Watterson

Cite this