TY - JOUR
T1 - Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach
AU - Katsoulis, Stavros
AU - Conlon, J. Michael
PY - 1988/12/13
Y1 - 1988/12/13
N2 - Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.
AB - Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.
KW - Neuromedin N
KW - Neurotensin
KW - Prostaglandins
KW - Stomach (guinea-pig)
KW - Xenopsin
UR - http://www.scopus.com/inward/record.url?scp=0024212843&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(88)90074-X
DO - 10.1016/0014-2999(88)90074-X
M3 - Article
C2 - 2855314
AN - SCOPUS:0024212843
SN - 0014-2999
VL - 158
SP - 251
EP - 256
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -