Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach

Stavros Katsoulis, J. Michael Conlon

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F and F with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished (in print/issue) - 13 Dec 1988


  • Neuromedin N
  • Neurotensin
  • Prostaglandins
  • Stomach (guinea-pig)
  • Xenopsin


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