Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: The aim of our study was to determine the relationship be- tween neuropeptide B (NPB), neuropeptide W (NPW), nutritional and anti- oxidant status and selected fat- and bone-derived factors in type 1 diabe- tes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free sol- uble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponec- tin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponec- tin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.
LanguageEnglish
Article number13
JournalArchives of Medical Science
Early online date16 May 2018
DOIs
Publication statusE-pub ahead of print - 16 May 2018

Fingerprint

Neuropeptides
Nutritional Status
Type 1 Diabetes Mellitus
Insulin
Pediatrics
Serum
Adiponectin
Leptin
Osteocalcin
Antioxidants
neuropeptide B
Control Groups
Polysorbates
Polymethyl Methacrylate
Cytoplasmic and Nuclear Receptors
Oxidants
ROC Curve
Fats

Keywords

  • insulin
  • type 1 diabetes mellitus
  • paediatric patients

Cite this

@article{3d7547bde2ef4916966095e89fe40aad,
title = "Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps",
abstract = "Introduction: The aim of our study was to determine the relationship be- tween neuropeptide B (NPB), neuropeptide W (NPW), nutritional and anti- oxidant status and selected fat- and bone-derived factors in type 1 diabe- tes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free sol- uble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33{\%}, p < 0.013; 34{\%}, p < 0.008; 290{\%}, p < 0.00004; 21{\%}, p < 0.05; respectively), while adiponec- tin was by 51{\%} higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36{\%} lower, p < 0.0009) and vs. the CONTR group (35{\%} lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponec- tin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.",
keywords = "insulin, type 1 diabetes mellitus, paediatric patients",
author = "{Naughton (nee Lesniewska)}, V",
year = "2018",
month = "5",
day = "16",
doi = "10.5114/aoms.2018.75818",
language = "English",
journal = "Archives of Medical Science",
issn = "1734-1922",

}

TY - JOUR

T1 - Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps

AU - Naughton (nee Lesniewska), V

PY - 2018/5/16

Y1 - 2018/5/16

N2 - Introduction: The aim of our study was to determine the relationship be- tween neuropeptide B (NPB), neuropeptide W (NPW), nutritional and anti- oxidant status and selected fat- and bone-derived factors in type 1 diabe- tes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free sol- uble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponec- tin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponec- tin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.

AB - Introduction: The aim of our study was to determine the relationship be- tween neuropeptide B (NPB), neuropeptide W (NPW), nutritional and anti- oxidant status and selected fat- and bone-derived factors in type 1 diabe- tes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free sol- uble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponec- tin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponec- tin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.

KW - insulin

KW - type 1 diabetes mellitus

KW - paediatric patients

UR - https://www.termedia.pl/Neuropeptide-B-and-neuropeptide-W-as-new-serum-predictors-of-nutritional-status-and-of-clinical-outcomes-in-pediatric-patients-with-type-1-diabetes-mellitus-treated-with-the-use-of-pens-or-insulin-pum,19,32795,0,1.html

U2 - 10.5114/aoms.2018.75818

DO - 10.5114/aoms.2018.75818

M3 - Article

JO - Archives of Medical Science

T2 - Archives of Medical Science

JF - Archives of Medical Science

SN - 1734-1922

M1 - 13

ER -