Neuroendocrine regulation of frog adrenocortical cells by neurotensin

F. Sicard, D. De Groot, M. Gras, J. Leprince, J. M. Conlon, E. W. Roubos, Hubert Vaudry, C. Delarue

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We previously characterized the primary structure of neurotensin (NT) from an extract of the intestine of the frog Rana esculenta. In this study, we provide evidence for the involvement of NT in the neurocrine regulation of the secretory activity of frog adrenocortical cells. Immunohistochemical studies revealed that the adrenal gland of R. esculenta is innervated by a dense network of NT-immunoreactive fibers. Graded concentrations of frog NT induced a dose-dependent stimulation of corticosterone and aldosterone secretion by frog adrenocortical explants through activation of two receptors with pEC 50 of 9.8 and 6.9. These data support the view that NT, released by nerve fibers within the frog adrenal gland, acts locally to control corticosteroid secretion.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalAnnals of the New York Academy of Sciences
Publication statusPublished (in print/issue) - 2005


  • Frog adrenal gland
  • Neurotensin
  • Steroidogenesis


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