Neuroendocrine regulation of frog adrenocortical cells by neurotensin

F. Sicard; D. De Groot; M. Gras; J. Leprince; J. M. Conlon; E. W. Roubos; Hubert Vaudry; C. Delarue

doi:10.1196/annals.1327.025

Neuroendocrine regulation of frog adrenocortical cells by neurotensin

F. Sicard, D. De Groot, M. Gras, J. Leprince, J. M. Conlon, E. W. Roubos, Hubert Vaudry, C. Delarue

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We previously characterized the primary structure of neurotensin (NT) from an extract of the intestine of the frog Rana esculenta. In this study, we provide evidence for the involvement of NT in the neurocrine regulation of the secretory activity of frog adrenocortical cells. Immunohistochemical studies revealed that the adrenal gland of R. esculenta is innervated by a dense network of NT-immunoreactive fibers. Graded concentrations of frog NT induced a dose-dependent stimulation of corticosterone and aldosterone secretion by frog adrenocortical explants through activation of two receptors with pEC ₅₀ of 9.8 and 6.9. These data support the view that NT, released by nerve fibers within the frog adrenal gland, acts locally to control corticosteroid secretion.

Original language	English
Pages (from-to)	200-205
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1040
DOIs	https://doi.org/10.1196/annals.1327.025
Publication status	Published (in print/issue) - 2005

Keywords

Frog adrenal gland
Neurotensin
Steroidogenesis

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10.1196/annals.1327.025

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abstract = "We previously characterized the primary structure of neurotensin (NT) from an extract of the intestine of the frog Rana esculenta. In this study, we provide evidence for the involvement of NT in the neurocrine regulation of the secretory activity of frog adrenocortical cells. Immunohistochemical studies revealed that the adrenal gland of R. esculenta is innervated by a dense network of NT-immunoreactive fibers. Graded concentrations of frog NT induced a dose-dependent stimulation of corticosterone and aldosterone secretion by frog adrenocortical explants through activation of two receptors with pEC 50 of 9.8 and 6.9. These data support the view that NT, released by nerve fibers within the frog adrenal gland, acts locally to control corticosteroid secretion.",

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T1 - Neuroendocrine regulation of frog adrenocortical cells by neurotensin

AU - Sicard, F.

AU - De Groot, D.

AU - Gras, M.

AU - Leprince, J.

AU - Conlon, J. M.

AU - Roubos, E. W.

AU - Vaudry, Hubert

AU - Delarue, C.

PY - 2005

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AB - We previously characterized the primary structure of neurotensin (NT) from an extract of the intestine of the frog Rana esculenta. In this study, we provide evidence for the involvement of NT in the neurocrine regulation of the secretory activity of frog adrenocortical cells. Immunohistochemical studies revealed that the adrenal gland of R. esculenta is innervated by a dense network of NT-immunoreactive fibers. Graded concentrations of frog NT induced a dose-dependent stimulation of corticosterone and aldosterone secretion by frog adrenocortical explants through activation of two receptors with pEC 50 of 9.8 and 6.9. These data support the view that NT, released by nerve fibers within the frog adrenal gland, acts locally to control corticosteroid secretion.

KW - Frog adrenal gland

KW - Neurotensin

KW - Steroidogenesis

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Neuroendocrine regulation of frog adrenocortical cells by neurotensin

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Keywords

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