Neural circuit function redundancy in brain disorders

Beatriz E P Mizusaki, Cian O'Donnell

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
74 Downloads (Pure)


Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalCurrent opinion in neurobiology
Early online date17 Aug 2021
Publication statusPublished (in print/issue) - 31 Oct 2021

Bibliographical note

Funding Information:
This work was supported by funding from the Simons Foundation Autism Research Initiative ( RPG-2019-229 ) and the Medical Research Council ( MR/S026630/1 ).

Publisher Copyright:
© 2021 The Author(s)


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