Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo; Nan Jiang; Jessica Moore; Colin McCoy; Monika Ziminska; Cormac Rafferty; Gianluca Sarri; Andrew Hamilton; Yubao Li; Li Zhang; Songsong Zhu; Dan Sun

doi:10.1021/acsami.9b04278

Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo
, Nan Jiang
, Jessica Moore
, Colin McCoy
, Monika Ziminska
, Cormac Rafferty
, Gianluca Sarri
, Andrew Hamilton
, Yubao Li
, Li Zhang
, Songsong Zhu
, Dan Sun

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.

Original language	English
Pages (from-to)	27269-27278
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	30
Early online date	19 Jun 2019
DOIs	https://doi.org/10.1021/acsami.9b04278
Publication status	Published (in print/issue) - 31 Jul 2019

Funding

The authors of this work would like to thank the fundingsupport from the Engineering and Physical Science ResearchCouncil (EPSRC, EP/P00394X/1 and EP/P010059/1), Na-tional Natural Science Foundation of China (no. 51673131),National Key Research and Development Program of China(2016YFA0201703/2016YFA0201700), and China Scholar-ship Council (201606240059)

Keywords

hybrid coating
tissue scaffold
multimodal therapy
co-drug delivery
photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.9b04278

Cite this

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AU - Guo, Zhijun

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AU - Moore, Jessica

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AU - Rafferty, Cormac

AU - Sarri, Gianluca

AU - Hamilton, Andrew

AU - Li, Yubao

AU - Zhang, Li

AU - Zhu, Songsong

AU - Sun, Dan

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Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Abstract

Funding

Keywords

UN SDGs

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