Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo; Nan Jiang; Jessica Moore; Colin McCoy; Monika Ziminska; Cormac Rafferty; Gianluca Sarri; Andrew Hamilton; Yubao Li; Li Zhang; Songsong Zhu; Dan Sun

doi:10.1021/acsami.9b04278

Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo, Nan Jiang, Jessica Moore, Colin McCoy, Monika Ziminska, Cormac Rafferty, Gianluca Sarri, Andrew Hamilton, Yubao Li, Li Zhang, Songsong Zhu, Dan Sun

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.

Original language	English
Pages (from-to)	27269-27278
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	30
Early online date	19 Jun 2019
DOIs	https://doi.org/10.1021/acsami.9b04278
Publication status	Published (in print/issue) - 31 Jul 2019

Keywords

hybrid coating
tissue scaffold
multimodal therapy
co-drug delivery
photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.9b04278

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abstract = "Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.",

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T1 - Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

AU - Guo, Zhijun

AU - Jiang, Nan

AU - Moore, Jessica

AU - McCoy, Colin

AU - Ziminska, Monika

AU - Rafferty, Cormac

AU - Sarri, Gianluca

AU - Hamilton, Andrew

AU - Li, Yubao

AU - Zhang, Li

AU - Zhu, Songsong

AU - Sun, Dan

PY - 2019/7/31

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KW - multimodal therapy

KW - co-drug delivery

KW - photothermal therapy

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Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Abstract

Keywords

UN SDGs

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