Nanoarchitectures in Management of Fungal Diseases: An Overview

Vijay Mishra, Manvendra Singh, Yachana Mishra, Nitin Charbe, Pallavi Nayak, Kalvatala Sudhakar, Alaa A. A. Aljabali, Seyed H. Shahcheraghi, Hamid Bakshi, Ángel Serrano-aroca, Murtaza M. Tambuwala

Research output: Contribution to journalReview articlepeer-review

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Abstract

Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of their mild existence and negligible resistance of infections to antifungal bioactivities. Nanotechnology-based carriers have gained much attention due to their magnificent abilities. Nanoarchitectures have served as excellent carriers/drug delivery systems (DDS) for delivering antifungal drugs with improved antifungal activities, bioavailability, targeted action, and reduced cytotoxicity. This review outlines the different fungal diseases and their treatment strategies involving various nanocarrier-based techniques such as liposomes, transfersomes, ethosomes, transethosomes, niosomes, spanlastics, dendrimers, polymeric nanoparticles, polymer nanocomposites, metallic nanoparticles, carbon nanomaterials, and nanoemulsions, among other nanotechnological approaches.
Original languageEnglish
Article numbere7119
Pages (from-to)1-19
Number of pages19
JournalApplied Sciences
Volume11
Issue number15
Early online date31 Jul 2021
DOIs
Publication statusE-pub ahead of print - 31 Jul 2021

Keywords

  • antifungal drugs
  • drug delivery
  • fungal infection
  • nanoarchitecture carriers

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