Myopes have significantly higher serum melatonin concentrations than non-myopes

Stephanie Kearney, Lisa O'Donoghue, L. Kirsty Pourshahidi, Diego Cobice, Kathryn J Saunders

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation. This study explored the association between myopia and serum concentrations of DA and Mel in humans.Methods: Morning serum concentrations of DA and Mel were measured by solid phase extraction-liquid chromatography-tandem mass spectrometry from 54 participants (age 19.1±0.81yrs) in September/October 2014 (Phase 1) and March/April 2016 (Phase 2). Axial length (AL), corneal radii (CR) and spherical equivalent refraction (SER) were also recorded. Participants were defined as myopic if non-cycloplegic spherical equivalent refractive error ≤-0.50DS at Phase 1. Results: Nine participants were lost to follow up. Mel concentrations were measurable for all myopes (phase 1 n=25, phase 2 n=22) and non-myopes (phase 1 n=29, phase 2 n=23). SER did not change significantly between Phases (p=0.51). DA concentrations were measurable for fewer myopes (phase 1 n=13, phase 2 n=12) and non-myopes (phase 1 n=23, phase 2 n=16). Myopes exhibited significantly higher Mel concentrations than non-myopes at phase 1 (Median difference:10pg/ml, p
LanguageEnglish
Pages557-567
JournalOPHTHALMIC AND PHYSIOLOGICAL OPTICS
Volume37
Issue number5
Early online date18 Jul 2017
DOIs
Publication statusE-pub ahead of print - 18 Jul 2017

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Melatonin
Dopamine
Serum
Myopia
Refractive Errors
Lost to Follow-Up
Solid Phase Extraction
Tandem Mass Spectrometry
Liquid Chromatography
Animal Models

Keywords

  • Myopia Circadian Rhythm Melatonin Dopamine

Cite this

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abstract = "Objective: Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation. This study explored the association between myopia and serum concentrations of DA and Mel in humans.Methods: Morning serum concentrations of DA and Mel were measured by solid phase extraction-liquid chromatography-tandem mass spectrometry from 54 participants (age 19.1±0.81yrs) in September/October 2014 (Phase 1) and March/April 2016 (Phase 2). Axial length (AL), corneal radii (CR) and spherical equivalent refraction (SER) were also recorded. Participants were defined as myopic if non-cycloplegic spherical equivalent refractive error ≤-0.50DS at Phase 1. Results: Nine participants were lost to follow up. Mel concentrations were measurable for all myopes (phase 1 n=25, phase 2 n=22) and non-myopes (phase 1 n=29, phase 2 n=23). SER did not change significantly between Phases (p=0.51). DA concentrations were measurable for fewer myopes (phase 1 n=13, phase 2 n=12) and non-myopes (phase 1 n=23, phase 2 n=16). Myopes exhibited significantly higher Mel concentrations than non-myopes at phase 1 (Median difference:10pg/ml, p",
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Myopes have significantly higher serum melatonin concentrations than non-myopes. / Kearney, Stephanie; O'Donoghue, Lisa; Pourshahidi, L. Kirsty; Cobice, Diego; Saunders, Kathryn J.

In: OPHTHALMIC AND PHYSIOLOGICAL OPTICS, Vol. 37, No. 5, 18.07.2017, p. 557-567.

Research output: Contribution to journalArticle

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AU - Kearney, Stephanie

AU - O'Donoghue, Lisa

AU - Pourshahidi, L. Kirsty

AU - Cobice, Diego

AU - Saunders, Kathryn J

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N2 - Objective: Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation. This study explored the association between myopia and serum concentrations of DA and Mel in humans.Methods: Morning serum concentrations of DA and Mel were measured by solid phase extraction-liquid chromatography-tandem mass spectrometry from 54 participants (age 19.1±0.81yrs) in September/October 2014 (Phase 1) and March/April 2016 (Phase 2). Axial length (AL), corneal radii (CR) and spherical equivalent refraction (SER) were also recorded. Participants were defined as myopic if non-cycloplegic spherical equivalent refractive error ≤-0.50DS at Phase 1. Results: Nine participants were lost to follow up. Mel concentrations were measurable for all myopes (phase 1 n=25, phase 2 n=22) and non-myopes (phase 1 n=29, phase 2 n=23). SER did not change significantly between Phases (p=0.51). DA concentrations were measurable for fewer myopes (phase 1 n=13, phase 2 n=12) and non-myopes (phase 1 n=23, phase 2 n=16). Myopes exhibited significantly higher Mel concentrations than non-myopes at phase 1 (Median difference:10pg/ml, p

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