Multiple Cost Optimisation for Alzheimer’s Disease Diagnosis

Niamh Mc Combe, Xuemei Ding, Girijesh Prasad, David Finn, Stephen Todd, Paula McClean, KongFatt Wong-Lin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

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Current machine learning techniques for dementia diagnosis often do not take into account real-world practical constraints, which may include, for example, the cost of diagnostic assessment time and financial budgets. In this work, we built on previous cost-sensitive feature selection approaches by generalising to multiple cost types, while taking into consideration that stakeholders attempting to optimise the dementia care pathway might face multiple non-fungible budget constraints. Our new optimisation algorithm involved the searching of cost-weighting hyperparameters while constrained by total budgets. We then provided a proof of concept using both assessment time cost and financial budget cost. We showed that budget constraints could control the feature selection process in an intuitive and practical manner, while adjusting the hyperparameter increased the range of solutions selected by feature selection. We further showed that our budget-constrained cost optimisation framework could be implemented in a user-friendly graphical user interface sandbox tool to encourage non-technical users and stakeholders to adopt and to further explore and audit the model - a humans-in-the-loop approach. Overall, we suggest that setting budget constraints initially and then fine tuning the cost-weighting hyperparameters can be an effective way to perform feature selection where multiple cost constraints exist, which will in turn lead to more realistic optimising and redesigning of dementia diagnostic assessments. Clinical Relevance-By optimising diagnostic accuracy against various costs (e.g. assessment administration time and financial budget) predictive yet practical dementia diagnostic assessments can be redesigned to suit clinical use.
Original languageEnglish
Title of host publication 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Number of pages7
ISBN (Electronic)978-1-7281-2782-8
ISBN (Print)978-1-7281-2783-5
Publication statusPublished (in print/issue) - 8 Sep 2022
EventThe 44th International Engineering in Medicine and Biology Conference (EMBC) - Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022

Publication series

ISSN (Print)2375-7477
ISSN (Electronic)2694-0604


ConferenceThe 44th International Engineering in Medicine and Biology Conference (EMBC)
Country/TerritoryUnited Kingdom


  • Costs
  • Process control
  • Machine learning
  • Feature extraction
  • Stakeholders
  • Medical diagnosis
  • Optimazation


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