Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue

Ana Marina Ferreira, Chiara Tonda-Turo, Elena Mancuso, Piergiorgio Gentile

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)
139 Downloads (Pure)


The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.

Original languageEnglish
Pages (from-to)22-38
Number of pages17
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Early online date17 Apr 2019
Publication statusPublished (in print/issue) - 1 Jul 2019


  • Layer-by-Layer assembly;
  • Nanocoatings
  • Nanoencapsulation
  • Bone regeneration
  • Bone disorders


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