TY - JOUR
T1 - Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue
AU - Ferreira, Ana Marina
AU - Tonda-Turo, Chiara
AU - Mancuso, Elena
AU - Gentile, Piergiorgio
PY - 2019/7/1
Y1 - 2019/7/1
N2 - The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.
AB - The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.
KW - Layer-by-Layer assembly;
KW - Nanocoatings
KW - Nanoencapsulation
KW - Bone regeneration
KW - Bone disorders
UR - http://www.scopus.com/inward/record.url?scp=85065720924&partnerID=8YFLogxK
UR - https://pure.ulster.ac.uk/en/publications/multilayer-nanoscale-functionalization-to-treat-disorders-and-enh
U2 - 10.1016/j.nano.2019.03.009
DO - 10.1016/j.nano.2019.03.009
M3 - Review article
C2 - 31002932
SN - 1549-9634
VL - 19
SP - 22
EP - 38
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
ER -