Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue

Ana Marina Ferreira, Chiara Tonda-Turo, Elena Mancuso, Piergiorgio Gentile

Research output: Contribution to journalReview article

Abstract

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.

LanguageEnglish
Pages22-38
Number of pages17
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume19
Early online date17 Apr 2019
DOIs
Publication statusPublished - 1 Jul 2019

Fingerprint

Regeneration
Bone
Multilayers
Geriatrics
Tissue
Bone and Bones
Equipment and Supplies
Coatings
Bone Regeneration
Regenerative Medicine
Surface Properties
Bone Development
Biomolecules
Medical applications
Cell Communication
Surface properties
Innovation
Technology
Growth
Pharmaceutical Preparations

Keywords

  • Layer-by-Layer assembly;
  • nanocoatings
  • nanoencapsulation
  • bone regeneration
  • bone disorders
  • Nanocoatings
  • Bone regeneration
  • Bone disorders
  • Layer-by-layer assembly
  • Nanoencapsulation

Cite this

@article{a22b85016a024b3d9b59cc5167a97f5e,
title = "Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue",
abstract = "The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16{\%} to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.",
keywords = "Layer-by-Layer assembly;, nanocoatings, nanoencapsulation, bone regeneration, bone disorders, Nanocoatings, Bone regeneration, Bone disorders, Layer-by-layer assembly, Nanoencapsulation",
author = "Ferreira, {Ana Marina} and Chiara Tonda-Turo and Elena Mancuso and Piergiorgio Gentile",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.nano.2019.03.009",
language = "English",
volume = "19",
pages = "22--38",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier",

}

Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue. / Ferreira, Ana Marina; Tonda-Turo, Chiara; Mancuso, Elena; Gentile, Piergiorgio.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 19, 01.07.2019, p. 22-38.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue

AU - Ferreira, Ana Marina

AU - Tonda-Turo, Chiara

AU - Mancuso, Elena

AU - Gentile, Piergiorgio

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.

AB - The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.

KW - Layer-by-Layer assembly;

KW - nanocoatings

KW - nanoencapsulation

KW - bone regeneration

KW - bone disorders

KW - Nanocoatings

KW - Bone regeneration

KW - Bone disorders

KW - Layer-by-layer assembly

KW - Nanoencapsulation

UR - http://www.scopus.com/inward/record.url?scp=85065720924&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2019.03.009

DO - 10.1016/j.nano.2019.03.009

M3 - Review article

VL - 19

SP - 22

EP - 38

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

T2 - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

ER -