A novel approach to the use and fabrication of disposable electrochemical sensors has been detailed. Metal foils are sandwiched between an insulating polymer with multiple, individually addressable layers built up to form the basis of a three-electrode sensor. Coring the laminate reveals a ring electrode configuration within a ``detection well with sample volume defined by the capillary filling of the void. A dip-extract-analyze sampling protocol was designed such that multiple sites within a single laminate strip can be used. The mechanical integrity of the construction has been assessed by electron microscopy and the electrochemical characteristics investigated using the oxidation of glucose as a model analyte. The reproducibility of the fabrication method has been evaluated with intra- and inter-RSD values for the analysis of 2 mM glucose lying within 5%.
Yonge, L., Isaac, A., Livingstone, C., & Davis, J. (2005). Multilayer laminated electrode assemblies: Integrated disposable sampling-sensing structures. Analytical Letters, 38(13), 2067-2076. https://doi.org/10.1080/00032710500259409