Multi-compartment centrifugal electrospinning based composite fibers

Li Wang, Zeeshan Ahmad, Jie Huang, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Multi-faceted technological advances in fiber science have proven to be invaluable in several emerging biomaterial and biomedical engineering applications. In the last decade, notable fiber engineering advances have been demonstrated ranging from co-axial flows (for micron and nano-scaled layering), non-concentric flows (for Janus composites) and even 3D printing (for controlled alignment). The ES process is however limited, both for commercial impact (low production rates) and also in its facile capability to deliver reliable mimicry of numerous biological tissues which comprise blended and aligned fibers (e.g. tendons and ligaments). In the technological advance demonstrated here, a combinatorial multi-compartment centrifugal electrospinning (CMCCE) system is developed and demonstrated. A proof-of-concept enabling multiple formulation solution hosting (including combinatorial grading) in a single centrifugal electrospinning system (CES) comprising one spinneret is shown. Using this process, controlled blending and tuning of resulting fibrous membrane properties (contact angle and active release behavior) via aligned and phased fiber mat composition is demonstrated. In addition, the CMCCE process is capable of replicating production rates of recently developed centrifugal electrospinning systems (∼120 g/h), while potentially permitting better mimicry of naturally occurring fibrous tissue blends. It is envisaged the advance in technology will be ideally suited to engineer synthetic fibrous biomaterials with greater host surface replication and will fulfil production rate requirements for the industrial sector.

LanguageEnglish
Pages541-549
Number of pages9
JournalChemical Engineering Journal
Volume330
DOIs
Publication statusPublished - 31 Jul 2017

Fingerprint

Electrospinning
mimicry
Fibers
Composite materials
Biocompatible Materials
Biomaterials
Fibrous membranes
Tissue
engineering
Biomedical engineering
Axial flow
Ligaments
Tendons
Contact angle
Printing
Tuning
membrane
Engineers
fibre
Chemical analysis

Keywords

  • Centrifugal electrospinning
  • Combinatorial
  • Composition
  • Fiber
  • Multi-compartment

Cite this

Wang, Li ; Ahmad, Zeeshan ; Huang, Jie ; Li, Jing Song ; Chang, Ming Wei. / Multi-compartment centrifugal electrospinning based composite fibers. 2017 ; Vol. 330. pp. 541-549.
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Multi-compartment centrifugal electrospinning based composite fibers. / Wang, Li; Ahmad, Zeeshan; Huang, Jie; Li, Jing Song; Chang, Ming Wei.

Vol. 330, 31.07.2017, p. 541-549.

Research output: Contribution to journalArticle

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