Morphology control of electrosprayed core-shell particles via collection media variation

Yuan Gao, Ding Zhao, Ming Wei Chang, Zeeshan Ahmad, Xiang Li, Hairui Suo, Jing Song Li

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The electrospraying process has been exploited in recent times to prepare micro- and nano-scaled polymer based particulate structures for a range of biomedical and pharmaceutical applications. Conventionally, three main parameters (applied voltage, flow rate and base solvent in processing polymeric media) are used to manipulate their morphologies during preparation (size, surface and porosity). In this work, an un-conventional approach is demonstrated to yield biocompatible core-shell encapsulated (poly-ε-caprolactone (PCL) and silicon oil) particles with a range of structural morphologies (i.e., spherical, hemi-spherical and oblate shaped). Retaining its advantageous single-step fabrication aspect and by using two co-axial needles, a range of collection media was used to demonstrate shape and size variation (from ~28-48 μm) using optical and scanning electron microscopy. The morphological variation is directly linked to surface tension of the collection liquid. In addition, the non-volatile and flexible nature of the oil core plays a role in geometry formation. In vitro release from these structures demonstrates significant and non-significant variations; providing pathways to control release as well mimic release profile but alter other biomedical process (e.g. ultrasound). These findings demonstrate an alternative approach to manipulate the shape of bi-phasic structures which is an important functional property in several biomedical remits (e.g. drug delivery and ultrasound).

LanguageEnglish
Pages59-64
Number of pages6
JournalMaterials Letters
Volume146
DOIs
Publication statusPublished - 1 May 2015

Fingerprint

Oils
Ultrasonics
Silicon
oils
Drug delivery
Needles
Drug products
Surface tension
Polymers
Porosity
Flow rate
retaining
Fabrication
needles
particulates
Scanning electron microscopy
Geometry
delivery
interfacial tension
Liquids

Keywords

  • Anisotropy
  • Biomaterials
  • Core-shell polymers
  • Electrospray
  • Microstructure

Cite this

Gao, Yuan ; Zhao, Ding ; Chang, Ming Wei ; Ahmad, Zeeshan ; Li, Xiang ; Suo, Hairui ; Li, Jing Song. / Morphology control of electrosprayed core-shell particles via collection media variation. 2015 ; Vol. 146. pp. 59-64.
@article{e4a8e4c3e241432cb1c710eaa89279e3,
title = "Morphology control of electrosprayed core-shell particles via collection media variation",
abstract = "The electrospraying process has been exploited in recent times to prepare micro- and nano-scaled polymer based particulate structures for a range of biomedical and pharmaceutical applications. Conventionally, three main parameters (applied voltage, flow rate and base solvent in processing polymeric media) are used to manipulate their morphologies during preparation (size, surface and porosity). In this work, an un-conventional approach is demonstrated to yield biocompatible core-shell encapsulated (poly-ε-caprolactone (PCL) and silicon oil) particles with a range of structural morphologies (i.e., spherical, hemi-spherical and oblate shaped). Retaining its advantageous single-step fabrication aspect and by using two co-axial needles, a range of collection media was used to demonstrate shape and size variation (from ~28-48 μm) using optical and scanning electron microscopy. The morphological variation is directly linked to surface tension of the collection liquid. In addition, the non-volatile and flexible nature of the oil core plays a role in geometry formation. In vitro release from these structures demonstrates significant and non-significant variations; providing pathways to control release as well mimic release profile but alter other biomedical process (e.g. ultrasound). These findings demonstrate an alternative approach to manipulate the shape of bi-phasic structures which is an important functional property in several biomedical remits (e.g. drug delivery and ultrasound).",
keywords = "Anisotropy, Biomaterials, Core-shell polymers, Electrospray, Microstructure",
author = "Yuan Gao and Ding Zhao and Chang, {Ming Wei} and Zeeshan Ahmad and Xiang Li and Hairui Suo and Li, {Jing Song}",
year = "2015",
month = "5",
day = "1",
doi = "10.1016/j.matlet.2015.02.013",
language = "English",
volume = "146",
pages = "59--64",

}

Morphology control of electrosprayed core-shell particles via collection media variation. / Gao, Yuan; Zhao, Ding; Chang, Ming Wei; Ahmad, Zeeshan; Li, Xiang; Suo, Hairui; Li, Jing Song.

Vol. 146, 01.05.2015, p. 59-64.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Morphology control of electrosprayed core-shell particles via collection media variation

AU - Gao, Yuan

AU - Zhao, Ding

AU - Chang, Ming Wei

AU - Ahmad, Zeeshan

AU - Li, Xiang

AU - Suo, Hairui

AU - Li, Jing Song

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The electrospraying process has been exploited in recent times to prepare micro- and nano-scaled polymer based particulate structures for a range of biomedical and pharmaceutical applications. Conventionally, three main parameters (applied voltage, flow rate and base solvent in processing polymeric media) are used to manipulate their morphologies during preparation (size, surface and porosity). In this work, an un-conventional approach is demonstrated to yield biocompatible core-shell encapsulated (poly-ε-caprolactone (PCL) and silicon oil) particles with a range of structural morphologies (i.e., spherical, hemi-spherical and oblate shaped). Retaining its advantageous single-step fabrication aspect and by using two co-axial needles, a range of collection media was used to demonstrate shape and size variation (from ~28-48 μm) using optical and scanning electron microscopy. The morphological variation is directly linked to surface tension of the collection liquid. In addition, the non-volatile and flexible nature of the oil core plays a role in geometry formation. In vitro release from these structures demonstrates significant and non-significant variations; providing pathways to control release as well mimic release profile but alter other biomedical process (e.g. ultrasound). These findings demonstrate an alternative approach to manipulate the shape of bi-phasic structures which is an important functional property in several biomedical remits (e.g. drug delivery and ultrasound).

AB - The electrospraying process has been exploited in recent times to prepare micro- and nano-scaled polymer based particulate structures for a range of biomedical and pharmaceutical applications. Conventionally, three main parameters (applied voltage, flow rate and base solvent in processing polymeric media) are used to manipulate their morphologies during preparation (size, surface and porosity). In this work, an un-conventional approach is demonstrated to yield biocompatible core-shell encapsulated (poly-ε-caprolactone (PCL) and silicon oil) particles with a range of structural morphologies (i.e., spherical, hemi-spherical and oblate shaped). Retaining its advantageous single-step fabrication aspect and by using two co-axial needles, a range of collection media was used to demonstrate shape and size variation (from ~28-48 μm) using optical and scanning electron microscopy. The morphological variation is directly linked to surface tension of the collection liquid. In addition, the non-volatile and flexible nature of the oil core plays a role in geometry formation. In vitro release from these structures demonstrates significant and non-significant variations; providing pathways to control release as well mimic release profile but alter other biomedical process (e.g. ultrasound). These findings demonstrate an alternative approach to manipulate the shape of bi-phasic structures which is an important functional property in several biomedical remits (e.g. drug delivery and ultrasound).

KW - Anisotropy

KW - Biomaterials

KW - Core-shell polymers

KW - Electrospray

KW - Microstructure

UR - http://www.scopus.com/inward/record.url?scp=84923311551&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2015.02.013

DO - 10.1016/j.matlet.2015.02.013

M3 - Article

VL - 146

SP - 59

EP - 64

ER -