Molecular signaling of G‐protein‐coupled receptor in chronic heart failure and associated complications

Mohammad Altamish, Vijaya Paul Samuel, Rajiv Dahiya, Yogendra Singh, Pran Kishore Deb, Hamid A. Bakshi, Murtaza M. Tambuwala, Dinesh K. Chellappan, Trudi Collet, Kamal Dua, Gaurav Gupta

Research output: Contribution to journalArticle

Abstract

The well-known condition of heart failure is a clinical syndrome that results when themyocardium's ability to pump enough blood to meet the body's metabolic needs isimpaired. Most of the cardiac activity is maintained by adrenoceptors, are categorizedinto two mainαandβand three distinct subtypes ofβreceptor:β1-,β2-, andβ3-adrenoceptors. Theβadrenoreceptor is the main regulatory macro proteins, pre-dominantly available on heart and responsible for down regulatory cardiac signaling.Moreover, the pathological involvement of Angiotensin-converting enzyme1 (ACE1)/angiotensin II (Ang II)/angiotensin II type 1 (AT1) axis and beneficial ACE2/Ang (1-7)/Mas receptor axis also shows protective role via Giβγ, during heart failurethese receptors get desensitized or internalized due to increase in the activity of G-protein-coupled receptor kinase 2 (GRK2) and GRK5, responsible for phosphorylationof G-protein-mediated down regulatory signaling. Here, we investigate the variousclinical and preclinical data that exhibit the molecular mechanism of upset level ofGRK change the cardiac activity during failing heart.
LanguageEnglish
Number of pages9
JournalDrug Development Research
Early online date30 Nov 2019
DOIs
Publication statusE-pub ahead of print - 30 Nov 2019

Fingerprint

G-Protein-Coupled Receptors
Heart Failure
Angiotensin II
Adrenergic Receptors
G-Protein-Coupled Receptor Kinase 2
Angiotensins
GTP-Binding Proteins
Proteins

Keywords

  • G-protein-coupled receptors
  • GPCR kinases
  • beta adrenoreceptor
  • chronic heart failure
  • extracellular receptor kinase1/2
  • mitogen-activated protein kinase
  • renin-angiotensin-aldosterone system

Cite this

Altamish, Mohammad ; Samuel, Vijaya Paul ; Dahiya, Rajiv ; Singh, Yogendra ; Deb, Pran Kishore ; Bakshi, Hamid A. ; Tambuwala, Murtaza M. ; Chellappan, Dinesh K. ; Collet, Trudi ; Dua, Kamal ; Gupta, Gaurav. / Molecular signaling of G‐protein‐coupled receptor in chronic heart failure and associated complications. In: Drug Development Research. 2019.
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Molecular signaling of G‐protein‐coupled receptor in chronic heart failure and associated complications. / Altamish, Mohammad; Samuel, Vijaya Paul; Dahiya, Rajiv; Singh, Yogendra; Deb, Pran Kishore; Bakshi, Hamid A.; Tambuwala, Murtaza M.; Chellappan, Dinesh K.; Collet, Trudi; Dua, Kamal; Gupta, Gaurav.

In: Drug Development Research, 30.11.2019.

Research output: Contribution to journalArticle

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