Abstract
The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P
| Original language | English |
|---|---|
| Pages (from-to) | 753-764 |
| Journal | Biological Chemistry |
| Volume | 397 |
| Issue number | 8 |
| Early online date | 10 Mar 2016 |
| DOIs | |
| Publication status | Published (in print/issue) - 1 Aug 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- tigerinin-1R
- insulin resistance
- high fat feeding
- insulin secretion
- antihyperglycaemic
Fingerprint
Dive into the research topics of 'Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver