Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

OO Ojo, DK Srinivasan, BO Owolabi, MK McGahon, Charlotte Moffett, TM Curtis, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P
Original languageEnglish
Pages (from-to)753-764
JournalBiological Chemistry
Volume397
Issue number8
Early online date10 Mar 2016
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • tigerinin-1R
  • insulin resistance
  • high fat feeding
  • insulin secretion
  • antihyperglycaemic

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