Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

OO Ojo; DK Srinivasan; BO Owolabi; MK McGahon; Charlotte Moffett; TM Curtis; JM Conlon; Peter Flatt; Yasser Abdel-Wahab

doi:10.1515/hsz-2016-0120

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

OO Ojo, DK Srinivasan, BO Owolabi, MK McGahon, Charlotte Moffett, TM Curtis, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P

Original language	English
Pages (from-to)	753-764
Journal	Biological Chemistry
Volume	397
Issue number	8
Early online date	10 Mar 2016
DOIs	https://doi.org/10.1515/hsz-2016-0120
Publication status	Published (in print/issue) - 1 Aug 2016

Keywords

tigerinin-1R
insulin resistance
high fat feeding
insulin secretion
antihyperglycaemic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/hsz-2016-0120

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abstract = "The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P",

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T1 - Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

AU - Ojo, OO

AU - Srinivasan, DK

AU - Owolabi, BO

AU - McGahon, MK

AU - Moffett, Charlotte

AU - Curtis, TM

AU - Conlon, JM

AU - Flatt, Peter

AU - Abdel-Wahab, Yasser

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P

AB - The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P

KW - tigerinin-1R

KW - insulin resistance

KW - high fat feeding

KW - insulin secretion

KW - antihyperglycaemic

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DO - 10.1515/hsz-2016-0120

M3 - Article

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VL - 397

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JO - Biological Chemistry

JF - Biological Chemistry

IS - 8

ER -

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

Abstract

Keywords

UN SDGs

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