Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

OO Ojo, DK Srinivasan, BO Owolabi, MK McGahon, Charlotte Moffett, TM Curtis, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P
LanguageEnglish
Pages753-764
JournalBiological Chemistry
Volume397
Issue number8
Early online date10 Mar 2016
DOIs
Publication statusPublished - 1 Aug 2016

Fingerprint

Nutrition
Insulin Resistance
Obesity
Insulin
Diet
Glucose
Peptides
Glucose Intolerance
Glucagon
Anura
Type 2 Diabetes Mellitus
Animal Models
Observation
Medical problems
Skin
Animals
Plasmas
In Vitro Techniques

Keywords

  • tigerinin-1R
  • insulin resistance
  • high fat feeding
  • insulin secretion
  • antihyperglycaemic

Cite this

@article{6f1a93049f4d428d9bd84615b7242b0a,
title = "Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance",
abstract = "The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P",
keywords = "tigerinin-1R, insulin resistance, high fat feeding, insulin secretion, antihyperglycaemic",
author = "OO Ojo and DK Srinivasan and BO Owolabi and MK McGahon and Charlotte Moffett and TM Curtis and JM Conlon and Peter Flatt and Yasser Abdel-Wahab",
year = "2016",
month = "8",
day = "1",
doi = "10.1515/hsz-2016-0120",
language = "English",
volume = "397",
pages = "753--764",
journal = "Biological Chemistry",
issn = "1431-6730",
number = "8",

}

Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance. / Ojo, OO; Srinivasan, DK; Owolabi, BO; McGahon, MK; Moffett, Charlotte; Curtis, TM; Conlon, JM; Flatt, Peter; Abdel-Wahab, Yasser.

In: Biological Chemistry, Vol. 397, No. 8, 01.08.2016, p. 753-764.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance

AU - Ojo, OO

AU - Srinivasan, DK

AU - Owolabi, BO

AU - McGahon, MK

AU - Moffett, Charlotte

AU - Curtis, TM

AU - Conlon, JM

AU - Flatt, Peter

AU - Abdel-Wahab, Yasser

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P

AB - The frog skin host-defense peptide tigerinin-1R stimulates insulin release in vitro and improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observation by investigating the molecular mechanisms of action underlying the beneficial metabolic effects of the analogue [Arg4]tigerinin-1R in mice with diet induced obesity, glucose intolerance and insulin resistance. The study also investigates the electrophysiological effects of the peptide on KATP and L-type Ca2+ channels in BRINBD11 clonal β cells. Non-fasting plasma glucose and glucagon concentrations were significantly (P

KW - tigerinin-1R

KW - insulin resistance

KW - high fat feeding

KW - insulin secretion

KW - antihyperglycaemic

U2 - 10.1515/hsz-2016-0120

DO - 10.1515/hsz-2016-0120

M3 - Article

VL - 397

SP - 753

EP - 764

JO - Biological Chemistry

T2 - Biological Chemistry

JF - Biological Chemistry

SN - 1431-6730

IS - 8

ER -