Modulation of ROS production in photodynamictherapy using a pH controlled photoinducedelectron transfer (PET) based sensitiser

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Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours
LanguageEnglish
Pages16832-16835
JournalChemical Communications
Volume15
DOIs
Publication statusPublished - 30 Sep 2015

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Photodynamic therapy
Bearings (structural)
Modulation
Heterografts
Tumors

Keywords

  • PDT
  • ROS
  • sensitiser
  • pH-controlled

Cite this

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title = "Modulation of ROS production in photodynamictherapy using a pH controlled photoinducedelectron transfer (PET) based sensitiser",
abstract = "A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours",
keywords = "PDT, ROS, sensitiser, pH-controlled",
author = "J Atchison and Sukanta Kamila and C McEwan and Heather Nesbitt and J Davis and Colin Fowley and Bridgeen Callan and AP McHale and John Callan",
year = "2015",
month = "9",
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doi = "10.1039/c5cc07022h",
language = "English",
volume = "15",
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journal = "Chemical Communications",
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publisher = "Royal Society of Chemistry",

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AU - Atchison, J

AU - Kamila, Sukanta

AU - McEwan, C

AU - Nesbitt, Heather

AU - Davis, J

AU - Fowley, Colin

AU - Callan, Bridgeen

AU - McHale, AP

AU - Callan, John

PY - 2015/9/30

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N2 - A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours

AB - A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours

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KW - ROS

KW - sensitiser

KW - pH-controlled

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DO - 10.1039/c5cc07022h

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EP - 16835

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T2 - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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