Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

J Atchison; Sukanta Kamila; C McEwan; Heather Nesbitt; J Davis; Colin Fowley; Bridgeen Callan; AP McHale; John Callan

doi:10.1039/c5cc07022h

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

J Atchison, Sukanta Kamila, C McEwan, Heather Nesbitt, J Davis, Colin Fowley, Bridgeen Callan, AP McHale, John Callan

Research output: Contribution to journal › Article › peer-review

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Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

Original language	English
Pages (from-to)	16832-16835
Number of pages	4
Journal	Chemical Communications
Volume	15
Early online date	30 Sept 2015
DOIs	https://doi.org/10.1039/c5cc07022h
Publication status	Published (in print/issue) - 7 Dec 2015

Keywords

PDT
ROS
sensitiser
pH-controlled

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c5cc07022h

Cite this

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abstract = "A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.",

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T1 - Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

AU - Atchison, J

AU - Kamila, Sukanta

AU - McEwan, C

AU - Nesbitt, Heather

AU - Davis, J

AU - Fowley, Colin

AU - Callan, Bridgeen

AU - McHale, AP

AU - Callan, John

PY - 2015/12/7

Y1 - 2015/12/7

N2 - A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

AB - A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

KW - PDT

KW - ROS

KW - sensitiser

KW - pH-controlled

UR - https://pure.ulster.ac.uk/en/publications/modulation-of-ros-production-in-photodynamictherapy-using-a-ph-co-3

UR - http://www.rsc.org/

U2 - 10.1039/c5cc07022h

DO - 10.1039/c5cc07022h

M3 - Article

SN - 1359-7345

VL - 15

SP - 16832

EP - 16835

JO - Chemical Communications

JF - Chemical Communications

ER -

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Abstract

Keywords

UN SDGs

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