A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
Atchison, J., Kamila, S., McEwan, C., Nesbitt, H., Davis, J., Fowley, C., Callan, B., McHale, AP., & Callan, J. (2015). Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser. Chemical Communications, 15, 16832-16835. https://doi.org/10.1039/c5cc07022h