Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

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Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
Original languageEnglish
Pages (from-to)16832-16835
Number of pages4
JournalChemical Communications
Volume15
Early online date30 Sep 2015
DOIs
Publication statusPublished - 7 Dec 2015

Keywords

  • PDT
  • ROS
  • sensitiser
  • pH-controlled

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    Anthony Mc Hale

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