Abstract
A new sensitiser (4) for use in photodynamic therapy (PDT) has beendeveloped to enable control of ROS production as a function of pH.This pH dependent PDT behaviour was tested in HeLa cells and in SCIDmice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
Original language | English |
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Pages (from-to) | 16832-16835 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 15 |
Early online date | 30 Sept 2015 |
DOIs | |
Publication status | Published (in print/issue) - 7 Dec 2015 |
Keywords
- PDT
- ROS
- sensitiser
- pH-controlled
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Dive into the research topics of 'Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser'. Together they form a unique fingerprint.Profiles
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Anthony McHale
- School of Pharm. & Pharmaceut. Sc. - Professor of Medical Biotechnology
- Faculty Of Life & Health Sciences - Full Professor
Person: Academic