Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system

A. Mathur; E. M. Hamad; S. Mukhopadhyay; S. S. Roy; J. A. McLaughlin

Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system

A. Mathur, E. M. Hamad, S. Mukhopadhyay, S. S. Roy, J. A. McLaughlin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ∼10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen - antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).

Original language	English
Title of host publication	Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures
Pages	32-37
Number of pages	6
Publication status	Published - 2010
Event	2009 MRS Fall Meeting - Boston, MA, United States Duration: 30 Nov 2009 → 4 Dec 2009

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1205
ISSN (Print)	0272-9172

Conference

Conference	2009 MRS Fall Meeting
Country	United States
City	Boston, MA
Period	30/11/09 → 4/12/09

Keywords

Bio-sensing
Carbon nanotubes (CNTs)
Hot embossing
Poly methyl meth acralate (PMMA)

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Mathur, A., Hamad, E. M., Mukhopadhyay, S., Roy, S. S., & McLaughlin, J. A. (2010). Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system. In Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures (pp. 32-37). (Materials Research Society Symposium Proceedings; Vol. 1205).

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title = "Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system",

abstract = "Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ∼10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen - antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).",

keywords = "Bio-sensing, Carbon nanotubes (CNTs), Hot embossing, Poly methyl meth acralate (PMMA)",

author = "A. Mathur and Hamad, {E. M.} and S. Mukhopadhyay and Roy, {S. S.} and McLaughlin, {J. A.}",

year = "2010",

language = "English",

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series = "Materials Research Society Symposium Proceedings",

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Mathur, A, Hamad, EM, Mukhopadhyay, S, Roy, SS & McLaughlin, JA 2010, Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system. in Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures. Materials Research Society Symposium Proceedings, vol. 1205, pp. 32-37, 2009 MRS Fall Meeting, Boston, MA, United States, 30/11/09.

Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system. / Mathur, A.; Hamad, E. M.; Mukhopadhyay, S.; Roy, S. S.; McLaughlin, J. A.

Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures. 2010. p. 32-37 (Materials Research Society Symposium Proceedings; Vol. 1205).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system

AU - Mathur, A.

AU - Hamad, E. M.

AU - Mukhopadhyay, S.

AU - Roy, S. S.

AU - McLaughlin, J. A.

PY - 2010

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N2 - Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ∼10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen - antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).

AB - Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ∼10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen - antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).

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KW - Hot embossing

KW - Poly methyl meth acralate (PMMA)

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BT - Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures

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