TY - CHAP
T1 - Microorganisms in Pathogenesis and Management of Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
AU - Selvakumar, Vijayalakshmi
AU - Manivel, Thenmozhi
AU - Chelliah, Ramachandran
AU - Barathikannan, Kaliyan
AU - Tyagi, Akanksha
AU - Chen, Xiuqin
AU - Shabbir, Umair
AU - Shan, Lingyue
AU - Pianpian, Yan
AU - Oh, Deog-Hwan
AU - Annamalai, Pannerselvam
PY - 2023/1/1
Y1 - 2023/1/1
N2 - ANCA-associated vasculitis (AAV) is characterized by granulomatous and neutrophilic tissue inflammation, and is commonly accompanied with the development of antibodies that target neutrophil antigens. The two major antigens targeted by ANCAs are leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO). The development of AAV has been linked to a number of potential risk aspects, including ecological, pharmacological, and microbial exposures. Infectious (microbial) factors are thought towards show a part in many types of vasculitis by causing inflammation of vessel walls as a result of direct or contiguous infection, type II or immune complex-mediated reaction, cell mediated allergic reaction, or inflammation caused by immune dysregulation triggered by bacterial toxin and/or super antigen production. Because immune suppressive medication in the absence of antimicrobial therapy may enhance morbidity while failing to resolve infection-related vascular inflammation, infectious entities should be considered as a potential inciting factor in vasculitis disorders. Therefore, amid these factors, here we contribute new consideration on infectious factors associated vasculitis.
AB - ANCA-associated vasculitis (AAV) is characterized by granulomatous and neutrophilic tissue inflammation, and is commonly accompanied with the development of antibodies that target neutrophil antigens. The two major antigens targeted by ANCAs are leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO). The development of AAV has been linked to a number of potential risk aspects, including ecological, pharmacological, and microbial exposures. Infectious (microbial) factors are thought towards show a part in many types of vasculitis by causing inflammation of vessel walls as a result of direct or contiguous infection, type II or immune complex-mediated reaction, cell mediated allergic reaction, or inflammation caused by immune dysregulation triggered by bacterial toxin and/or super antigen production. Because immune suppressive medication in the absence of antimicrobial therapy may enhance morbidity while failing to resolve infection-related vascular inflammation, infectious entities should be considered as a potential inciting factor in vasculitis disorders. Therefore, amid these factors, here we contribute new consideration on infectious factors associated vasculitis.
UR - http://dx.doi.org/10.1007/978-981-19-4800-8_16
U2 - 10.1007/978-981-19-4800-8_16
DO - 10.1007/978-981-19-4800-8_16
M3 - Chapter
SN - 9789811947995
SN - 9789811948008
SP - 311
EP - 339
BT - Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases
ER -
