Abstract
Microneedles (MNs) are microscopic needles that are applied to the
skin in a minimally invasive way to facilitate transdermal drug delivery
and/or uptake of interstitial fuid from the skin, which contains a variety
of metabolites that can serve as biomarkers. The collection of interstitial
fuid can be followed by post-sampling analysis or in situ real-time
biosensing for disease diagnosis and drug monitoring. The painless
and easy administration of MNs is appealing to patients, especially
for long-term monitoring. In this Review, we discuss the use of MNs for
biosensing purposes. We highlight the diferent types of MNs and
sensing technologies used to develop MN-based biosensors. In addition,
we discuss the potential to integrate MNs with wearable devices for realtime monitoring to improve point-of-care testing. Finally, we review the
translational hurdles to be considered in bringing this technology from
benchtop to bedside.
skin in a minimally invasive way to facilitate transdermal drug delivery
and/or uptake of interstitial fuid from the skin, which contains a variety
of metabolites that can serve as biomarkers. The collection of interstitial
fuid can be followed by post-sampling analysis or in situ real-time
biosensing for disease diagnosis and drug monitoring. The painless
and easy administration of MNs is appealing to patients, especially
for long-term monitoring. In this Review, we discuss the use of MNs for
biosensing purposes. We highlight the diferent types of MNs and
sensing technologies used to develop MN-based biosensors. In addition,
we discuss the potential to integrate MNs with wearable devices for realtime monitoring to improve point-of-care testing. Finally, we review the
translational hurdles to be considered in bringing this technology from
benchtop to bedside.
Original language | English |
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Pages (from-to) | 64-81 |
Number of pages | 18 |
Journal | Nature Reviews Bioengineering |
Volume | 2 |
Early online date | 26 Sept 2023 |
DOIs | |
Publication status | Published (in print/issue) - 31 Jan 2024 |
Keywords
- Diagnostic markers
- Sensors and probes