Microneedle-based biosensing

Lalitkumar K. Vora, Akmal H. Sabri, Peter E. McKenna, Achmad Himawan, Aaron R. J. Hutton, Usanee Detamornrat, Alejandro J. Paredes, Eneko Larrañeta, Ryan F. Donnelly

Research output: Contribution to journalReview articlepeer-review


Microneedles (MNs) are microscopic needles that are applied to the
skin in a minimally invasive way to facilitate transdermal drug delivery
and/or uptake of interstitial fuid from the skin, which contains a variety
of metabolites that can serve as biomarkers. The collection of interstitial
fuid can be followed by post-sampling analysis or in situ real-time
biosensing for disease diagnosis and drug monitoring. The painless
and easy administration of MNs is appealing to patients, especially
for long-term monitoring. In this Review, we discuss the use of MNs for
biosensing purposes. We highlight the diferent types of MNs and
sensing technologies used to develop MN-based biosensors. In addition,
we discuss the potential to integrate MNs with wearable devices for realtime monitoring to improve point-of-care testing. Finally, we review the
translational hurdles to be considered in bringing this technology from
benchtop to bedside.
Original languageEnglish
Pages (from-to)64-81
Number of pages18
JournalNature Reviews Bioengineering
Early online date26 Sept 2023
Publication statusPublished (in print/issue) - 31 Jan 2024


  • Diagnostic markers
  • Sensors and probes


Dive into the research topics of 'Microneedle-based biosensing'. Together they form a unique fingerprint.

Cite this