TY - JOUR
T1 - Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug
AU - Kastner, Elisabeth
AU - Verma, Varun
AU - Lowry, Deborah
AU - Perrie, Yvonne
PY - 2015/5/15
Y1 - 2015/5/15
N2 - Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.
AB - Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.
KW - Liposomes
KW - Microfluidics
KW - Poorly soluble drugs
KW - Bilayer loading
KW - High throughput
UR - https://pure.ulster.ac.uk/en/publications/microfluidic-controlled-manufacture-of-liposomes-for-the-solubili
U2 - 10.1016/j.ijpharm.2015.02.063
DO - 10.1016/j.ijpharm.2015.02.063
M3 - Article
VL - 485
SP - 122
EP - 130
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -