Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.
- Poorly soluble drugs
- Bilayer loading
- High throughput
Kastner, E., Verma, V., Lowry, D., & Perrie, Y. (2015). Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug. International Journal of Pharmaceutics, 485(1-2), 122-130. https://doi.org/10.1016/j.ijpharm.2015.02.063