Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou; Colin Fowley; Niall M. Byrne; Bridgeen McCaughan; AP MCHALE; John F. Callan

doi:10.1039/c2cc33913g

Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou
, Colin Fowley
, Niall M. Byrne
, Bridgeen McCaughan
, AP MCHALE
, John F. Callan

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

Original language	English
Pages (from-to)	8332-8334
Journal	Chemical Communications
Volume	48
Issue number	67
DOIs	https://doi.org/10.1039/c2cc33913g
Publication status	Published (in print/issue) - 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c2cc33913g

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title = "Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy",

abstract = "A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.",

author = "Nikolitsa Nomikou and Colin Fowley and Byrne, \{Niall M.\} and Bridgeen McCaughan and AP MCHALE and Callan, \{John F.\}",

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language = "English",

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AU - Nomikou, Nikolitsa

AU - Fowley, Colin

AU - Byrne, Niall M.

AU - McCaughan, Bridgeen

AU - MCHALE, AP

AU - Callan, John F.

PY - 2012

Y1 - 2012

N2 - A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

AB - A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

U2 - 10.1039/c2cc33913g

DO - 10.1039/c2cc33913g

M3 - Article

SN - 1364-548X

VL - 48

SP - 8332

EP - 8334

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

Abstract

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