Microbubble-enhanced ultrasound-mediated gene transfer - Towards the development of targeted gene therapy for cancer

Nikoleta Nomikou, AP MCHALE

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ultrasound-mediated gene transfer is emerging as a possible alternative to viral gene transfer, and pre-clinical data suggest that it may play a significant role in gene therapy-based approaches to the treatment of disease. As an extracorporeal stimulus, ultrasound can non-invasively and transiently compromise cell membrane permeability (sonoporation), thereby offering the promise of delivering either genes or oligonucleotide-based therapeutics to cells and tissues in a site-specific manner. The membrane-permeabilising effects of ultrasound can be greatly enhanced using microbubble preparations, many of which have, in the past, found application as ultrasound contrast agents. Because these ultrasound-responsive agents are highly amenable to surface modification it has been suggested that they may be exploited as ultrasound-responsive nucleic acid delivery vehicles. In this article we seek to explore the potential role ultrasound, in combination with microbubble-based agents, may play in providing site-specific gene therapy-based approaches for the treatment of cancer.
Original languageEnglish
Pages (from-to)300-310
JournalInt. J. Hyperthermia
Volume28
Issue number4
DOIs
Publication statusPublished - 16 Jan 2012

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