Microbiome Medicine: Microbiota in Development and Management of Cardiovascular Diseases

Yogesh Garg, Navjot Kanwar, Hemraj Dodiya, Shruti Chopra, Murtaza Tambuwala, Amit Bhatia, Abhinav Kanwal

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The gut microbiome consists of trillions of bacteria and other microbes whose metabolic activities and interactions with the immune system go beyond the gut itself. We are all aware that bacteria and other microorganisms have a significant impact on our health. Also, the health of the bacteria directly reflects the health status of the body where they reside. Eventually, alterations in the microbiome at different sites of a body are associated with many different diseases such as obesity, IBD, malnutrition, CVD, etc. Microbiota directly or indirectly affects the heart with the formation of plaques in the blood vessels, and cell walls become prone to lesion development. This ultimately leads to heightening the overall inflammatory status via increased bacterial translocation. Metabolites derived from the gut microbial metabolism of choline, phosphatidylcholine, and L-carnitine directly contribute to CVD pathology. These dietary nutrients have trimethylamine (TMA) moiety, which participates in the development of atherosclerotic heart disease. The objective of this review was to examine various metabolic pathways regulated by the gut microbiome that appear to alter heart function and lead to the development and progression of cardiovascular diseases, as well as how to target the gut microbiome for a healthier heart. In this review, we also discussed various clinical drugs having crosstalk between microbiota and heart and clinical trials for the gut-heart microbiome.
Original languageEnglish
Pages (from-to)1344-1356
Number of pages13
JournalEndocrine, Metabolic & Immune Disorders - Drug Targets
Volume22
Issue number14
DOIs
Publication statusPublished (in print/issue) - 24 Jun 2022

Bibliographical note

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Keywords

  • Gut microbiome
  • cardiovascular disease
  • drugs
  • gut dysbiosis
  • heart failure
  • metabolism
  • synbiotics

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