Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome

Thomas Alderson, Arun L. W. Bokde, Scott Kelso, Liam Maguire, Damien Coyle

Research output: Contribution to journalArticle

5 Citations (Scopus)
17 Downloads (Pure)

Abstract

Current theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dependent upon the structural connectivity between brain regions. In Alzheimer’s disease (AD) – the most common form of dementia – these
couplings are progressively weakened, metastability of neural dynamics are reduced and cognitive ability is impaired. Accordingly, we use a joint empirical and computational approach to reveal how behaviourally relevant changes in neural metastability are contingent on the structural integrity of the anatomical connectome. We estimate the metastability of fMRI BOLD signal in subjects from across the AD spectrum and in healthy controls and demonstrate the dissociable effects of structural disconnection on synchrony versus metastability. In addition, we reveal the critical role of metastability in general cognition by demonstrating the link between an individuals cognitive performance and their
metastable neural dynamic. Finally, using whole-brain computer modelling, we
demonstrate how a healthy neural dynamic is conditioned upon the topological integrity of the structural connectome. Overall, the results of our joint computational and empirical analysis suggest an important causal relationship between metastable neural dynamics, cognition, and the structural efficiency of the anatomical connectome.
Original languageEnglish
Pages (from-to)438-455
Number of pages18
JournalNeuroImage
Volume183
Early online date18 Aug 2018
DOIs
Publication statusPublished - 31 Dec 2018

Keywords

  • Alzheimer’s disease
  • whole-brain modelling
  • Kuramoto
  • DTI
  • structural connectome
  • metastability

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