Metabolic mimics: Thiol responsive drug release

IA Solsona, RB Smith, C Livingstone, J Davis

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    A new approach to the design of selective release interfaces is assessed in which a hydrophobic component is functionalised with a receptor reactive toward reduced thiol peptides-principally glutathione. The assembly has been characterised using electrochemical techniques and its ability to form a coherent, water insoluble coating is demonstrated. The subsequent reaction with glutathione creates a supramolecular conjugate that exploits the hydrophilic nature of the amino acid chain as a route through which the protective coating can be eroded and hence the underlying substrate exposed. The efficacy of the release process has been critically assessed with a view to establishing the action and selectivity of the trigger mechanism. (c) 2006 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)698-701
    JournalJournal of Colloid and Interface Science
    Volume302
    Issue number2
    DOIs
    Publication statusPublished - Oct 2006

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