Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.

Nigel Irwin; P Frizzelle; Finbarr O'Harte; Peter Flatt

doi:10.1530/JOE-12-0353

Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.

Nigel Irwin, P Frizzelle, Finbarr O'Harte, Peter Flatt

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P

Original language	English
Pages (from-to)	53-59
Journal	Journal of Endrocrinology
Volume	216
Issue number	1
DOIs	https://doi.org/10.1530/JOE-12-0353
Publication status	Published (in print/issue) - 2 Jan 2013

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AU - Frizzelle, P

AU - O'Harte, Finbarr

AU - Flatt, Peter

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AB - Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P

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Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.

Abstract

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