Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.

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Abstract

Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P
LanguageEnglish
Pages53-59
JournalJournal of Endrocrinology
Volume216
Issue number1
DOIs
Publication statusPublished - 2 Jan 2013

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Cholecystokinin Receptors
Cholecystokinin
Enzymes
Body Weight
Hormones
Injections
Metabolic Activation
cholecystokinin 8

Cite this

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title = "Metabolic effects of activation of CCK receptor signaling pathways by twice daily administration of the enzyme resistant CCK-8 analogue, (pGlu-Gln)-CCK-8, in normal mice.",
abstract = "Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P",
author = "Nigel Irwin and P Frizzelle and Finbarr O'Harte and Peter Flatt",
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AU - Irwin, Nigel

AU - Frizzelle, P

AU - O'Harte, Finbarr

AU - Flatt, Peter

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N2 - Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P

AB - Cholecystokinin (CCK) is a hormone that has important physiological effects on energy balance. This study has utilized a stable CCK1 receptor agonist, (pGlu-Gln)-CCK-8, to evaluate the metabolic effects of prolonged administration in normal mice. Twice daily injection of (pGlu-Gln)-CCK-8 for 28 days resulted in significantly lowered body weights (P

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