M/EEG-Based Bio-Markers to Predict the MCI and Alzheimer's Disease: A Review From the ML Perspective

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This paper reviews the state-of-the-art neuromarkers development for the prognosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The first part of this paper is devoted to reviewing the recently emerged machine learning (ML) algorithms based on electroencephalography (EEG) and magnetoencephalography (MEG) modalities. In particular, the methods are categorized by different types of neuromarkers. The second part of the review is dedicated to a series of investigations that further highlight the differences between these two modalities. First, several source reconstruction methods are reviewed and their source-level performances explored, followed by an objective comparison between EEG and MEG from multiple perspectives. Finally, a number of the most recent reports on classification of MCI/AD during resting state using EEG/MEG are documented to show the up-to-date performance for this well-recognized data collecting scenario. It is noticed that the MEG modality may be particularly effective in distinguishing between subjects with MCI and healthy controls, a high classification accuracy of more than 98% was reported recently; whereas the EEG seems to be performing well in classifying AD and healthy subjects, which also reached around 98% of the accuracy. A number of influential factors have also been raised and suggested for careful considerations while evaluating the ML-based diagnosis systems in the real-world scenarios.

Original languageEnglish
Article number8640065
Pages (from-to)2924-2935
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Issue number10
Early online date12 Feb 2019
Publication statusPublished (in print/issue) - 31 Oct 2019


  • Alzheimer's disease
  • biomarkers
  • EEG
  • MEG
  • mild cognitive impairment
  • neuromarkers


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