Mechanisms of weight loss after obesity surgery

Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
250 Downloads (Pure)

Abstract

Obesity surgery remains the most effective treatment for obesity and its complications. Weight loss was initially attributed to decreased energy absorption from the gut but has since been linked to reduced appetitive behavior and potentially increased energy expenditure. Implicated mechanisms associating rearrangement of the gastrointestinal tract with these metabolic outcomes include central appetite control, release of gut peptides, change in microbiota, and bile acids. However, the exact combination and timing of signals remain largely unknown. In this review, we survey recent research investigating these mechanisms, and seek to provide insights on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.

Original languageEnglish
Pages (from-to)19-34
Number of pages16
JournalEndocrine Reveiws
Volume43
Issue number1
Early online date7 Aug 2021
DOIs
Publication statusPublished - 12 Jan 2022

Bibliographical note

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • gut hormones
  • weight loss
  • Obesity surgery
  • eating behavior
  • energy expenditure

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