Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

C. G. Owen, A. R. Rudnicka, R. Mullen, S. A. Barman, Dorothy Monekosso, P. H. Whincup, J. Ng, C. Paterson

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Abstract

    PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P
    LanguageEnglish
    Pages2004-2010
    JournalINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
    Volume50
    Issue number5
    Publication statusPublished - 1 May 2009

    Fingerprint

    Retinal Vessels
    Computer-Assisted Image Processing
    Retina
    Arterioles
    Veins
    Software
    Cross-Sectional Studies
    Regression Analysis

    Keywords

    • Arterioles/pathology
    • Child
    • Cross-Sectional Studies
    • Humans
    • Image Processing
    • Computer-Assisted/methods
    • Observer Variation
    • Reproducibility of Results
    • Retinal Diseases/diagnosis
    • Retinal Vessels/pathology
    • Venules/pathology

    Cite this

    Owen, C. G., Rudnicka, A. R., Mullen, R., Barman, S. A., Monekosso, D., Whincup, P. H., ... Paterson, C. (2009). Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(5), 2004-2010.
    Owen, C. G. ; Rudnicka, A. R. ; Mullen, R. ; Barman, S. A. ; Monekosso, Dorothy ; Whincup, P. H. ; Ng, J. ; Paterson, C. / Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2009 ; Vol. 50, No. 5. pp. 2004-2010.
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    abstract = "PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56{\%} of grades and 42{\%} differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P",
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    author = "Owen, {C. G.} and Rudnicka, {A. R.} and R. Mullen and Barman, {S. A.} and Dorothy Monekosso and Whincup, {P. H.} and J. Ng and C. Paterson",
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    Owen, CG, Rudnicka, AR, Mullen, R, Barman, SA, Monekosso, D, Whincup, PH, Ng, J & Paterson, C 2009, 'Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 50, no. 5, pp. 2004-2010.

    Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program. / Owen, C. G.; Rudnicka, A. R.; Mullen, R.; Barman, S. A.; Monekosso, Dorothy; Whincup, P. H.; Ng, J.; Paterson, C.

    In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 50, No. 5, 01.05.2009, p. 2004-2010.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

    AU - Owen, C. G.

    AU - Rudnicka, A. R.

    AU - Mullen, R.

    AU - Barman, S. A.

    AU - Monekosso, Dorothy

    AU - Whincup, P. H.

    AU - Ng, J.

    AU - Paterson, C.

    N1 - id: 1; GR: 068362/Z/02/Z/Wellcome Trust/United Kingdom; JID: 7703701; 2009/03/25 [aheadofprint]; ppublish

    PY - 2009/5/1

    Y1 - 2009/5/1

    N2 - PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P

    AB - PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P

    KW - Arterioles/pathology

    KW - Child

    KW - Cross-Sectional Studies

    KW - Humans

    KW - Image Processing

    KW - Computer-Assisted/methods

    KW - Observer Variation

    KW - Reproducibility of Results

    KW - Retinal Diseases/diagnosis

    KW - Retinal Vessels/pathology

    KW - Venules/pathology

    M3 - Article

    VL - 50

    SP - 2004

    EP - 2010

    JO - Investigative Ophthalmology and Visual Science

    T2 - Investigative Ophthalmology and Visual Science

    JF - Investigative Ophthalmology and Visual Science

    SN - 0146-0404

    IS - 5

    ER -