Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

C. G. Owen; A. R. Rudnicka; R. Mullen; S. A. Barman; Dorothy Monekosso; P. H. Whincup; J. Ng; C. Paterson

Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

C. G. Owen, A. R. Rudnicka, R. Mullen, S. A. Barman, Dorothy Monekosso, P. H. Whincup, J. Ng, C. Paterson

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P

Original language	English
Pages (from-to)	2004-2010
Journal	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume	50
Issue number	5
Publication status	Published (in print/issue) - 1 May 2009

Bibliographical note

id: 1; GR: 068362/Z/02/Z/Wellcome Trust/United Kingdom; JID: 7703701; 2009/03/25 [aheadofprint]; ppublish

Keywords

Arterioles/pathology
Child
Cross-Sectional Studies
Humans
Image Processing
Computer-Assisted/methods
Observer Variation
Reproducibility of Results
Retinal Diseases/diagnosis
Retinal Vessels/pathology
Venules/pathology

Cite this

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title = "Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program",

abstract = "PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P",

keywords = "Arterioles/pathology, Child, Cross-Sectional Studies, Humans, Image Processing, Computer-Assisted/methods, Observer Variation, Reproducibility of Results, Retinal Diseases/diagnosis, Retinal Vessels/pathology, Venules/pathology",

author = "Owen, {C. G.} and Rudnicka, {A. R.} and R. Mullen and Barman, {S. A.} and Dorothy Monekosso and Whincup, {P. H.} and J. Ng and C. Paterson",

note = "id: 1; GR: 068362/Z/02/Z/Wellcome Trust/United Kingdom; JID: 7703701; 2009/03/25 [aheadofprint]; ppublish",

year = "2009",

month = may,

day = "1",

language = "English",

volume = "50",

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publisher = "Association for Research in Vision and Ophthalmology",

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TY - JOUR

T1 - Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

AU - Owen, C. G.

AU - Rudnicka, A. R.

AU - Mullen, R.

AU - Barman, S. A.

AU - Monekosso, Dorothy

AU - Whincup, P. H.

AU - Ng, J.

AU - Paterson, C.

N1 - id: 1; GR: 068362/Z/02/Z/Wellcome Trust/United Kingdom; JID: 7703701; 2009/03/25 [aheadofprint]; ppublish

PY - 2009/5/1

Y1 - 2009/5/1

N2 - PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P

AB - PURPOSE: To examine the agreement of a novel computer program measuring retinal vessel tortuosity with subjective assessment of tortuosity in school-aged children. METHODS: Cross-sectional study of 387 retinal vessels (193 arterioles, 194 veins) from 28 eyes of 14 children (aged 10 years). Retinal digital images were analyzed using the Computer Assisted Image Analysis of the Retina (CAIAR) program, including 14 measures of tortuosity. Vessels were graded (from 0 = none; to 5 = tortuous) independently by two observers. Interobserver agreement was assessed by using kappa statistics. Agreement with all 14 objective measures was assessed with correlation/regression analyses. Intersession repeatability (comparing morning and afternoon sessions) of tortuosity indices was calculated. RESULTS: Interobserver agreement of vessel tortuosity within one grade was high (kappa = 0.97), with total agreement in 56% of grades and 42% differing by +/-1 grade. Tortuosity indices based on subdivided chord length methods showed strong log-linear associations with agreed subjective grades (typically r > 0.6; P

KW - Arterioles/pathology

KW - Child

KW - Cross-Sectional Studies

KW - Humans

KW - Image Processing

KW - Computer-Assisted/methods

KW - Observer Variation

KW - Reproducibility of Results

KW - Retinal Diseases/diagnosis

KW - Retinal Vessels/pathology

KW - Venules/pathology

M3 - Article

VL - 50

SP - 2004

EP - 2010

JO - INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

JF - INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

IS - 5

ER -

Measuring retinal vessel tortuosity in 10-year-old children: validation of the Computer-Assisted Image Analysis of the Retina (CAIAR) program

Abstract

Bibliographical note

Keywords

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