Measurements of immune responses for establishing correlates of vaccine protection against HIV

WA Burgers; A Manrique; D Masopust; LR McKinnon; MR Reynolds; M Rolland; C Blish; GK Chege; Rhonda M Curran; W Fischer; C Herrera; N Sather

doi:10.1089/aid.2011.0239

Measurements of immune responses for establishing correlates of vaccine protection against HIV

WA Burgers, A Manrique, D Masopust, LR McKinnon, MR Reynolds, M Rolland, C Blish, GK Chege, Rhonda M Curran, W Fischer, C Herrera, N Sather

Research output: Contribution to journal › Article › peer-review

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Abstract

Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

Original language	English
Pages (from-to)	641-648
Journal	AIDS Research and Human Retroviruses
Volume	28
Issue number	7
DOIs	https://doi.org/10.1089/aid.2011.0239
Publication status	Published (in print/issue) - 2012

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10.1089/aid.2011.0239

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abstract = "Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.",

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T1 - Measurements of immune responses for establishing correlates of vaccine protection against HIV

AU - Burgers, WA

AU - Manrique, A

AU - Masopust, D

AU - McKinnon, LR

AU - Reynolds, MR

AU - Rolland, M

AU - Blish, C

AU - Chege, GK

AU - Curran, Rhonda M

AU - Fischer, W

AU - Herrera, C

AU - Sather, N

PY - 2012

Y1 - 2012

N2 - Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

AB - Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

U2 - 10.1089/aid.2011.0239

DO - 10.1089/aid.2011.0239

M3 - Article

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EP - 648

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 7

ER -

Measurements of immune responses for establishing correlates of vaccine protection against HIV

Abstract

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