Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects

Aine McKillop, JR Lindsay, S Au, KI Mahood, Finbarr O'Harte, Peter Flatt, PM Bell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44% carbohydrate; 40% fat; 16% protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p <0.001), representing 22% total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.
LanguageEnglish
Pages94-97
JournalHORMONE AND METABOLIC RESEARCH
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 2006

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Meals
Insulin
Glucose
C-Peptide
Insulin-Secreting Cells
Enteral Nutrition
Type 2 Diabetes Mellitus
Small Intestine
Insulin Resistance
Homeostasis
Fats
Carbohydrates
glycosylated insulin
Proteins

Cite this

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title = "Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects",
abstract = "There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44{\%} carbohydrate; 40{\%} fat; 16{\%} protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p <0.001), representing 22{\%} total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.",
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Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects. / McKillop, Aine; Lindsay, JR; Au, S; Mahood, KI; O'Harte, Finbarr; Flatt, Peter; Bell, PM.

In: HORMONE AND METABOLIC RESEARCH, Vol. 38, No. 2, 02.2006, p. 94-97.

Research output: Contribution to journalArticle

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AU - Bell, PM

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AB - There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44% carbohydrate; 40% fat; 16% protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p <0.001), representing 22% total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.

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