Maternal vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: Results from the Seychelles Child Development Nutrition Study

Eamon Laird, Sally Thurston, Edwin van Wijngaarden, Conrad Shamlaye, Gary Myers, Philip Davidson, Gene Watson, E. M. McSorley, Maria S. Mulhern, Alison J. Yeates, Mary Ward, Helene McNulty, JJ Strain

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Abstract

Vitamin D has an important role in early life; however, the optimal vitamin D statusduring pregnancy is currently unclear. There have been recent calls for pregnant women tomaintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yetlittle is known about the long-term potential benefits or safety of achieving such high maternal25(OH)D concentrations for infant or child health outcomes. We examined maternal vitaminD status and its associations with infant anthropometric and later childhood neurocognitiveoutcomes in a mother-child cohort in a sun-rich country near the equator (4.6◦ S). This study wasconducted in pregnant mothers originally recruited to the Seychelles Child Development NutritionStudy. Blood samples (n = 202) taken at delivery were analysed for serum 25-hydroxyvitaminD (25(OH)D) concentrations. Multiple linear regression models assessed associations betweenmaternal 25(OH)D and birth weight, infant head circumference, and neurocognitive outcomes inthe children at age 5 years. Mothers were, on average, 27 years of age, and the children’s averagegestational age was 39 weeks. None of the women reported any intake of vitamin D supplements.Maternal 25(OH)D concentrations had a mean of 101 (range 34–218 nmol/L) and none were deficient(
Original languageEnglish
Pages (from-to)1235-1247
JournalNutrients
Volume9
Issue number11
Early online date11 Nov 2017
DOIs
Publication statusE-pub ahead of print - 11 Nov 2017

Keywords

  • vitamin D
  • pregnancy
  • birth
  • childhood
  • neurodevelopment
  • health

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