Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles.

JJ Strain, Philip W Davidson, Sally W Thurston, Donald Harrington, Maria S. Mulhern, Alison McAfee, Edwin van Wijngaarden, Conrad F Shamlaye, Juliette Henderson, Gene E Watson, Grazyna Zareba, Deborah A Cory-Slechta, Miranda Lynch, JMW Wallace, E. M. McSorley, Maxine P. Bonham, Abbie Stokes-Riner, Jean Sloane-Reeves, Joanne Janciuras, Rosa Wong & 2 others Thomas W Clarkson, Gary J Myers

Research output: Contribution to journalArticle

Abstract

Evidence from the Seychelles Child Development Nutrition Study suggests that maternal nutritional status can modulate the relationship between prenatal methylmercury (MeHg) exposure and developmental outcomes in children. The aim of this study was to investigate whether maternal PUFA status was a confounding factor in any possible associations between prenatal MeHg exposure and developmental outcomes at 5 y of age in the Republic of Seychelles. Maternal status of (n-3) and (n-6) PUFA were measured in serum collected at 28 wk gestation and delivery. Prenatal MeHg exposure was determined in maternal hair collected at delivery. At 5 y of age, the children completed a comprehensive range of sensitive developmental assessments. Complete data from 225 mothers and their children were available for analysis. Multiple linear regression analyses revealed Preschool Language Scale scores of the children improved with increasing maternal serum DHA [22:6(n-3)] concentrations and decreased with increasing arachidonic acid [20:4(n-6)] concentrations, albeit verbal intelligence improved with increasing (n-6) PUFA concentrations in maternal serum. There were no adverse associations between MeHg exposure and developmental outcomes. These findings suggest that higher fish consumption, resulting in higher maternal (n-3) PUFA status, during pregnancy is associated with beneficial developmental effects rather than detrimental effects resulting from the higher concomitant exposures of the fetus to MeHg. The association of maternal (n-3) PUFA status with improved child language development may partially explain the authors' previous finding of improving language scores, as prenatal MeHg exposure increased in an earlier mother-child cohort in the Seychelles where maternal PUFA status was not measured.
LanguageEnglish
Pagesin -press
JournalJournal of Nutrition
Volume142
Publication statusPublished - 2012

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Seychelles
Child Language
Mothers
Omega-3 Fatty Acids
Child Development
Language
Serum
Pregnancy
Language Development
Nutritional Status
Intelligence
Arachidonic Acid
Hair

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Strain, JJ ; Davidson, Philip W ; Thurston, Sally W ; Harrington, Donald ; Mulhern, Maria S. ; McAfee, Alison ; van Wijngaarden, Edwin ; Shamlaye, Conrad F ; Henderson, Juliette ; Watson, Gene E ; Zareba, Grazyna ; Cory-Slechta, Deborah A ; Lynch, Miranda ; Wallace, JMW ; McSorley, E. M. ; Bonham, Maxine P. ; Stokes-Riner, Abbie ; Sloane-Reeves, Jean ; Janciuras, Joanne ; Wong, Rosa ; Clarkson, Thomas W ; Myers, Gary J. / Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles. In: Journal of Nutrition. 2012 ; Vol. 142. pp. in -press.
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title = "Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles.",
abstract = "Evidence from the Seychelles Child Development Nutrition Study suggests that maternal nutritional status can modulate the relationship between prenatal methylmercury (MeHg) exposure and developmental outcomes in children. The aim of this study was to investigate whether maternal PUFA status was a confounding factor in any possible associations between prenatal MeHg exposure and developmental outcomes at 5 y of age in the Republic of Seychelles. Maternal status of (n-3) and (n-6) PUFA were measured in serum collected at 28 wk gestation and delivery. Prenatal MeHg exposure was determined in maternal hair collected at delivery. At 5 y of age, the children completed a comprehensive range of sensitive developmental assessments. Complete data from 225 mothers and their children were available for analysis. Multiple linear regression analyses revealed Preschool Language Scale scores of the children improved with increasing maternal serum DHA [22:6(n-3)] concentrations and decreased with increasing arachidonic acid [20:4(n-6)] concentrations, albeit verbal intelligence improved with increasing (n-6) PUFA concentrations in maternal serum. There were no adverse associations between MeHg exposure and developmental outcomes. These findings suggest that higher fish consumption, resulting in higher maternal (n-3) PUFA status, during pregnancy is associated with beneficial developmental effects rather than detrimental effects resulting from the higher concomitant exposures of the fetus to MeHg. The association of maternal (n-3) PUFA status with improved child language development may partially explain the authors' previous finding of improving language scores, as prenatal MeHg exposure increased in an earlier mother-child cohort in the Seychelles where maternal PUFA status was not measured.",
author = "JJ Strain and Davidson, {Philip W} and Thurston, {Sally W} and Donald Harrington and Mulhern, {Maria S.} and Alison McAfee and {van Wijngaarden}, Edwin and Shamlaye, {Conrad F} and Juliette Henderson and Watson, {Gene E} and Grazyna Zareba and Cory-Slechta, {Deborah A} and Miranda Lynch and JMW Wallace and McSorley, {E. M.} and Bonham, {Maxine P.} and Abbie Stokes-Riner and Jean Sloane-Reeves and Joanne Janciuras and Rosa Wong and Clarkson, {Thomas W} and Myers, {Gary J}",
year = "2012",
language = "English",
volume = "142",
pages = "in --press",
journal = "Journal of Nutrition",
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Strain, JJ, Davidson, PW, Thurston, SW, Harrington, D, Mulhern, MS, McAfee, A, van Wijngaarden, E, Shamlaye, CF, Henderson, J, Watson, GE, Zareba, G, Cory-Slechta, DA, Lynch, M, Wallace, JMW, McSorley, EM, Bonham, MP, Stokes-Riner, A, Sloane-Reeves, J, Janciuras, J, Wong, R, Clarkson, TW & Myers, GJ 2012, 'Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles.', Journal of Nutrition, vol. 142, pp. in -press.

Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles. / Strain, JJ; Davidson, Philip W; Thurston, Sally W; Harrington, Donald; Mulhern, Maria S.; McAfee, Alison; van Wijngaarden, Edwin; Shamlaye, Conrad F; Henderson, Juliette; Watson, Gene E; Zareba, Grazyna; Cory-Slechta, Deborah A; Lynch, Miranda; Wallace, JMW; McSorley, E. M.; Bonham, Maxine P.; Stokes-Riner, Abbie; Sloane-Reeves, Jean; Janciuras, Joanne; Wong, Rosa; Clarkson, Thomas W; Myers, Gary J.

In: Journal of Nutrition, Vol. 142, 2012, p. in -press.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles.

AU - Strain, JJ

AU - Davidson, Philip W

AU - Thurston, Sally W

AU - Harrington, Donald

AU - Mulhern, Maria S.

AU - McAfee, Alison

AU - van Wijngaarden, Edwin

AU - Shamlaye, Conrad F

AU - Henderson, Juliette

AU - Watson, Gene E

AU - Zareba, Grazyna

AU - Cory-Slechta, Deborah A

AU - Lynch, Miranda

AU - Wallace, JMW

AU - McSorley, E. M.

AU - Bonham, Maxine P.

AU - Stokes-Riner, Abbie

AU - Sloane-Reeves, Jean

AU - Janciuras, Joanne

AU - Wong, Rosa

AU - Clarkson, Thomas W

AU - Myers, Gary J

PY - 2012

Y1 - 2012

N2 - Evidence from the Seychelles Child Development Nutrition Study suggests that maternal nutritional status can modulate the relationship between prenatal methylmercury (MeHg) exposure and developmental outcomes in children. The aim of this study was to investigate whether maternal PUFA status was a confounding factor in any possible associations between prenatal MeHg exposure and developmental outcomes at 5 y of age in the Republic of Seychelles. Maternal status of (n-3) and (n-6) PUFA were measured in serum collected at 28 wk gestation and delivery. Prenatal MeHg exposure was determined in maternal hair collected at delivery. At 5 y of age, the children completed a comprehensive range of sensitive developmental assessments. Complete data from 225 mothers and their children were available for analysis. Multiple linear regression analyses revealed Preschool Language Scale scores of the children improved with increasing maternal serum DHA [22:6(n-3)] concentrations and decreased with increasing arachidonic acid [20:4(n-6)] concentrations, albeit verbal intelligence improved with increasing (n-6) PUFA concentrations in maternal serum. There were no adverse associations between MeHg exposure and developmental outcomes. These findings suggest that higher fish consumption, resulting in higher maternal (n-3) PUFA status, during pregnancy is associated with beneficial developmental effects rather than detrimental effects resulting from the higher concomitant exposures of the fetus to MeHg. The association of maternal (n-3) PUFA status with improved child language development may partially explain the authors' previous finding of improving language scores, as prenatal MeHg exposure increased in an earlier mother-child cohort in the Seychelles where maternal PUFA status was not measured.

AB - Evidence from the Seychelles Child Development Nutrition Study suggests that maternal nutritional status can modulate the relationship between prenatal methylmercury (MeHg) exposure and developmental outcomes in children. The aim of this study was to investigate whether maternal PUFA status was a confounding factor in any possible associations between prenatal MeHg exposure and developmental outcomes at 5 y of age in the Republic of Seychelles. Maternal status of (n-3) and (n-6) PUFA were measured in serum collected at 28 wk gestation and delivery. Prenatal MeHg exposure was determined in maternal hair collected at delivery. At 5 y of age, the children completed a comprehensive range of sensitive developmental assessments. Complete data from 225 mothers and their children were available for analysis. Multiple linear regression analyses revealed Preschool Language Scale scores of the children improved with increasing maternal serum DHA [22:6(n-3)] concentrations and decreased with increasing arachidonic acid [20:4(n-6)] concentrations, albeit verbal intelligence improved with increasing (n-6) PUFA concentrations in maternal serum. There were no adverse associations between MeHg exposure and developmental outcomes. These findings suggest that higher fish consumption, resulting in higher maternal (n-3) PUFA status, during pregnancy is associated with beneficial developmental effects rather than detrimental effects resulting from the higher concomitant exposures of the fetus to MeHg. The association of maternal (n-3) PUFA status with improved child language development may partially explain the authors' previous finding of improving language scores, as prenatal MeHg exposure increased in an earlier mother-child cohort in the Seychelles where maternal PUFA status was not measured.

M3 - Article

VL - 142

SP - in -press

JO - Journal of Nutrition

T2 - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

ER -