Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Jessica L. Irwin; Emeir M. McSorley; Alison J. Yeates; Maria S. Mulhern; J. J. Strain; Gene E. Watson; Katherine Grzesik; Sally W. Thurston; Tanzy M. Love; Tristram H. Smith; Karin Broberg; Conrad F. Shamlaye; Gary J. Myers; Philip W. Davidson; Edwin van Wijngaarden

doi:10.1016/j.jneuroim.2019.577023

Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Jessica L. Irwin
, Emeir M. McSorley
, Alison J. Yeates
, Maria S. Mulhern
, J. J. Strain
, Gene E. Watson
, Katherine Grzesik
, Sally W. Thurston
, Tanzy M. Love
, Tristram H. Smith
, Karin Broberg
, Conrad F. Shamlaye
, Gary J. Myers
, Philip W. Davidson
, Edwin van Wijngaarden

Nutrition Innovation Centre for Food and Health

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

174 Downloads (Pure)

Abstract

Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

Original language	English
Article number	577023
Journal	Journal of Neuroimmunology
Volume	335
Early online date	14 Aug 2019
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577023
Publication status	Published (in print/issue) - 15 Oct 2019

Funding

This research was supported by grants R01-ES010219 , P30-ES01247 , R03-ES027514 , and T32-ES007026 from the United States National Institute of Environmental Health Sciences ( National Institutes of Health ) and in-kind by the Government of the Republic of Seychelles . We acknowledge with thanks the contribution of the nursing and laboratory teams in Seychelles. The study sponsors had no role in the design, collection, analysis, or interpretation of the data; in the writing of the report; or in the decision to submit the article for publication. The authors declare they have no conflicts of interest.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Children
Developmental outcomes
Inflammatory markers
Pregnancy

Access to Document

10.1016/j.jneuroim.2019.577023

Irwin et al J of Neuroimmunology NC2 manuscript finalAuthor Accepted Manuscript, 279 KBLicence: CC BY-NC-ND

Cite this

Irwin, J. L., McSorley, E. M., Yeates, A. J., Mulhern, M. S., Strain, J. J., Watson, G. E., Grzesik, K., Thurston, S. W., Love, T. M., Smith, T. H., Broberg, K., Shamlaye, C. F., Myers, G. J., Davidson, P. W., & van Wijngaarden, E. (2019). Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study. Journal of Neuroimmunology, 335, Article 577023. https://doi.org/10.1016/j.jneuroim.2019.577023

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title = "Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study",

abstract = "Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.",

keywords = "Children, Developmental outcomes, Inflammatory markers, Pregnancy",

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year = "2019",

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doi = "10.1016/j.jneuroim.2019.577023",

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Irwin, JL, McSorley, EM , Yeates, AJ , Mulhern, MS , Strain, JJ, Watson, GE, Grzesik, K, Thurston, SW, Love, TM, Smith, TH, Broberg, K, Shamlaye, CF, Myers, GJ, Davidson, PW & van Wijngaarden, E 2019, 'Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study', Journal of Neuroimmunology, vol. 335, 577023. https://doi.org/10.1016/j.jneuroim.2019.577023

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T1 - Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

AU - Irwin, Jessica L.

AU - McSorley, Emeir M.

AU - Yeates, Alison J.

AU - Mulhern, Maria S.

AU - Strain, J. J.

AU - Watson, Gene E.

AU - Grzesik, Katherine

AU - Thurston, Sally W.

AU - Love, Tanzy M.

AU - Smith, Tristram H.

AU - Broberg, Karin

AU - Shamlaye, Conrad F.

AU - Myers, Gary J.

AU - Davidson, Philip W.

AU - van Wijngaarden, Edwin

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

AB - Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

KW - Children

KW - Developmental outcomes

KW - Inflammatory markers

KW - Pregnancy

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UR - https://pure.ulster.ac.uk/en/publications/maternal-immune-markers-during-pregnancy-and-child-neurodevelopme

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VL - 335

JO - Journal of Neuroimmunology

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M1 - 577023

ER -

Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Abstract

Funding

UN SDGs

Keywords

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Emeir McSorley

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Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Abstract

Funding

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Profiles

Emeir McSorley

Cite this