Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Jessica L. Irwin; Emeir M. McSorley; Alison J. Yeates; Maria S. Mulhern; J. J. Strain; Gene E. Watson; Katherine Grzesik; Sally W. Thurston; Tanzy M. Love; Tristram H. Smith; Karin Broberg; Conrad F. Shamlaye; Gary J. Myers; Philip W. Davidson; Edwin van Wijngaarden

doi:10.1016/j.jneuroim.2019.577023

Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Jessica L. Irwin, Emeir M. McSorley, Alison J. Yeates, Maria S. Mulhern, J. J. Strain, Gene E. Watson, Katherine Grzesik, Sally W. Thurston, Tanzy M. Love, Tristram H. Smith, Karin Broberg, Conrad F. Shamlaye, Gary J. Myers, Philip W. Davidson, Edwin van Wijngaarden

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Abstract

Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

Original language	English
Article number	577023
Journal	Journal of Neuroimmunology
Volume	335
Early online date	14 Aug 2019
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577023
Publication status	Published (in print/issue) - 15 Oct 2019

Keywords

Children
Developmental outcomes
Inflammatory markers
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jneuroim.2019.577023

Irwin et al J of Neuroimmunology NC2 manuscript finalAuthor Accepted Manuscript, 279 KBLicence: CC BY-NC-ND

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Irwin, J. L., McSorley, E. M., Yeates, A. J., Mulhern, M. S., Strain, J. J., Watson, G. E., Grzesik, K., Thurston, S. W., Love, T. M., Smith, T. H., Broberg, K., Shamlaye, C. F., Myers, G. J., Davidson, P. W., & van Wijngaarden, E. (2019). Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study. Journal of Neuroimmunology, 335, [577023]. https://doi.org/10.1016/j.jneuroim.2019.577023

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title = "Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study",

abstract = "Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.",

keywords = "Children, Developmental outcomes, Inflammatory markers, Pregnancy",

author = "Irwin, {Jessica L.} and McSorley, {Emeir M.} and Yeates, {Alison J.} and Mulhern, {Maria S.} and Strain, {J. J.} and Watson, {Gene E.} and Katherine Grzesik and Thurston, {Sally W.} and Love, {Tanzy M.} and Smith, {Tristram H.} and Karin Broberg and Shamlaye, {Conrad F.} and Myers, {Gary J.} and Davidson, {Philip W.} and {van Wijngaarden}, Edwin",

year = "2019",

month = oct,

day = "15",

doi = "10.1016/j.jneuroim.2019.577023",

language = "English",

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Irwin, JL, McSorley, EM , Yeates, AJ , Mulhern, MS , Strain, JJ, Watson, GE, Grzesik, K, Thurston, SW, Love, TM, Smith, TH, Broberg, K, Shamlaye, CF, Myers, GJ, Davidson, PW & van Wijngaarden, E 2019, 'Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study', Journal of Neuroimmunology, vol. 335, 577023. https://doi.org/10.1016/j.jneuroim.2019.577023

TY - JOUR

T1 - Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

AU - Irwin, Jessica L.

AU - McSorley, Emeir M.

AU - Yeates, Alison J.

AU - Mulhern, Maria S.

AU - Strain, J. J.

AU - Watson, Gene E.

AU - Grzesik, Katherine

AU - Thurston, Sally W.

AU - Love, Tanzy M.

AU - Smith, Tristram H.

AU - Broberg, Karin

AU - Shamlaye, Conrad F.

AU - Myers, Gary J.

AU - Davidson, Philip W.

AU - van Wijngaarden, Edwin

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

AB - Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

KW - Children

KW - Developmental outcomes

KW - Inflammatory markers

KW - Pregnancy

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UR - https://pure.ulster.ac.uk/en/publications/maternal-immune-markers-during-pregnancy-and-child-neurodevelopme

U2 - 10.1016/j.jneuroim.2019.577023

DO - 10.1016/j.jneuroim.2019.577023

M3 - Article

C2 - 31445378

AN - SCOPUS:85070880041

SN - 0165-5728

VL - 335

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577023

ER -

Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

Abstract

Keywords

UN SDGs

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