Maternal age specific risk of non-chromosomal anomalies

Maria Loane, Helen Dolk, Joan Morris, Working Group EUROCAT

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: To determine the excess risk of non-chromosomal congenital anomaly (NCA) among teenage mothers and older mothers. DESIGN AND SETTING: Population-based prevalence study using data from EUROCAT congenital anomaly registers in 23 regions of Europe in 15 countries, covering a total of 1.75 million births from 2000 to 2004. PARTICIPANTS: A total of 38,958 cases of NCA that were live births, fetal deaths with gestational age > or = 20 weeks or terminations of pregnancy following prenatal diagnosis of a congenital anomaly. MAIN OUTCOME MEASURES: Prevalence of NCA according to maternal age, and relative risk (RR) of NCA and 84 standard NCA subgroups compared with mothers aged 25-29. RESULTS: The crude prevalence of all NCA was 26.5 per 1000 births in teenage mothers (
Original languageEnglish
Pages (from-to)1111-1119
JournalBritish Journal of Obstetrics & Gynaecology
Issue number8
Publication statusPublished (in print/issue) - Jul 2009


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