Marginal copper deficiency and atherosclerosis

IMJ Hamilton, WS Gilmore, JJ Strain

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Copper is an essential trace element in the maintenance of the cardiovascular system. Copper-deficient diets can elicit, in animals, structural and functional changes that are comparable to those observed in coronary heart disease. In this study, the effect of dietary induced copper deficiency on aortic lesion development was measured by quantitative image analysis in C57BL/6 mice that are susceptible to diet-induced aortic lesions. The diets administered were severely copper deficient (0.2 mg/kg diet), marginally deficient (0.6 mg/kg diet), or copper adequate (6.0 mg/kg diet). Similarly, increased aortic lesion areas and elevated serum cholesterol were demonstrated in both deficient groups, compared with the copper-adequate group. Evidence for graded differences in copper status among the dietary groups was shown by the dose-response increase in liver copper concentration, copper-zinc superoxide dismutase and cytochrome-c oxidase activities, together with serum caeruloplasmin oxidase with increasing intakes of dietary copper. Despite the difference in copper status between the copper marginal and severely deficient groups, similar lesions found in both groups of mice suggest a threshold effect of copper deficiency on lesion formation.
LanguageEnglish
Pages179-189
JournalBiological Trace Element Research
Volume78
Issue number1-3
Publication statusPublished - 2000

Fingerprint

Copper
Atherosclerosis
Diet
Ceruloplasmin
Trace Elements
Electron Transport Complex IV
Cardiovascular System
Hypercholesterolemia
Serum
Inbred C57BL Mouse
Superoxide Dismutase
Coronary Disease
Zinc
Oxidoreductases
Maintenance
Liver

Cite this

Hamilton, IMJ ; Gilmore, WS ; Strain, JJ. / Marginal copper deficiency and atherosclerosis. In: Biological Trace Element Research. 2000 ; Vol. 78, No. 1-3. pp. 179-189.
@article{7e0d41b158cc46db8c230474cd740aab,
title = "Marginal copper deficiency and atherosclerosis",
abstract = "Copper is an essential trace element in the maintenance of the cardiovascular system. Copper-deficient diets can elicit, in animals, structural and functional changes that are comparable to those observed in coronary heart disease. In this study, the effect of dietary induced copper deficiency on aortic lesion development was measured by quantitative image analysis in C57BL/6 mice that are susceptible to diet-induced aortic lesions. The diets administered were severely copper deficient (0.2 mg/kg diet), marginally deficient (0.6 mg/kg diet), or copper adequate (6.0 mg/kg diet). Similarly, increased aortic lesion areas and elevated serum cholesterol were demonstrated in both deficient groups, compared with the copper-adequate group. Evidence for graded differences in copper status among the dietary groups was shown by the dose-response increase in liver copper concentration, copper-zinc superoxide dismutase and cytochrome-c oxidase activities, together with serum caeruloplasmin oxidase with increasing intakes of dietary copper. Despite the difference in copper status between the copper marginal and severely deficient groups, similar lesions found in both groups of mice suggest a threshold effect of copper deficiency on lesion formation.",
author = "IMJ Hamilton and WS Gilmore and JJ Strain",
year = "2000",
language = "English",
volume = "78",
pages = "179--189",
journal = "Biological Trace Element Research",
issn = "0163-4984",
number = "1-3",

}

Hamilton, IMJ, Gilmore, WS & Strain, JJ 2000, 'Marginal copper deficiency and atherosclerosis', Biological Trace Element Research, vol. 78, no. 1-3, pp. 179-189.

Marginal copper deficiency and atherosclerosis. / Hamilton, IMJ; Gilmore, WS; Strain, JJ.

In: Biological Trace Element Research, Vol. 78, No. 1-3, 2000, p. 179-189.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Marginal copper deficiency and atherosclerosis

AU - Hamilton, IMJ

AU - Gilmore, WS

AU - Strain, JJ

PY - 2000

Y1 - 2000

N2 - Copper is an essential trace element in the maintenance of the cardiovascular system. Copper-deficient diets can elicit, in animals, structural and functional changes that are comparable to those observed in coronary heart disease. In this study, the effect of dietary induced copper deficiency on aortic lesion development was measured by quantitative image analysis in C57BL/6 mice that are susceptible to diet-induced aortic lesions. The diets administered were severely copper deficient (0.2 mg/kg diet), marginally deficient (0.6 mg/kg diet), or copper adequate (6.0 mg/kg diet). Similarly, increased aortic lesion areas and elevated serum cholesterol were demonstrated in both deficient groups, compared with the copper-adequate group. Evidence for graded differences in copper status among the dietary groups was shown by the dose-response increase in liver copper concentration, copper-zinc superoxide dismutase and cytochrome-c oxidase activities, together with serum caeruloplasmin oxidase with increasing intakes of dietary copper. Despite the difference in copper status between the copper marginal and severely deficient groups, similar lesions found in both groups of mice suggest a threshold effect of copper deficiency on lesion formation.

AB - Copper is an essential trace element in the maintenance of the cardiovascular system. Copper-deficient diets can elicit, in animals, structural and functional changes that are comparable to those observed in coronary heart disease. In this study, the effect of dietary induced copper deficiency on aortic lesion development was measured by quantitative image analysis in C57BL/6 mice that are susceptible to diet-induced aortic lesions. The diets administered were severely copper deficient (0.2 mg/kg diet), marginally deficient (0.6 mg/kg diet), or copper adequate (6.0 mg/kg diet). Similarly, increased aortic lesion areas and elevated serum cholesterol were demonstrated in both deficient groups, compared with the copper-adequate group. Evidence for graded differences in copper status among the dietary groups was shown by the dose-response increase in liver copper concentration, copper-zinc superoxide dismutase and cytochrome-c oxidase activities, together with serum caeruloplasmin oxidase with increasing intakes of dietary copper. Despite the difference in copper status between the copper marginal and severely deficient groups, similar lesions found in both groups of mice suggest a threshold effect of copper deficiency on lesion formation.

M3 - Article

VL - 78

SP - 179

EP - 189

JO - Biological Trace Element Research

T2 - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

IS - 1-3

ER -