Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study

L.M. Rea; D. McMaster; J. Donnelly; L.T. McGrath; I.S. Young

doi:10.1196/annals.1297.070

Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study

L.M. Rea, D. McMaster, J. Donnelly, L.T. McGrath, I.S. Young

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Citations (Scopus)

Abstract

Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.

Original language	English
Title of host publication	Unknown Host Publication
Publisher	The New York Academy of Sciences
Pages	392-395
Number of pages	4
Volume	1019
DOIs	https://doi.org/10.1196/annals.1297.070
Publication status	Published - 2004
Event	Unkown - Duration: 1 Jan 2004 → …

Conference

Conference	Unkown
Period	1/01/04 → …

Keywords

Aging
Glutathione
Glutathione peroxidase
Malondialdehyde

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Rea, L. M., McMaster, D., Donnelly, J., McGrath, L. T., & Young, I. S. (2004). Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. In Unknown Host Publication (Vol. 1019, pp. 392-395). The New York Academy of Sciences. https://doi.org/10.1196/annals.1297.070

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Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. / Rea, L.M.; McMaster, D.; Donnelly, J.; McGrath, L.T.; Young, I.S.

Unknown Host Publication. Vol. 1019 The New York Academy of Sciences, 2004. p. 392-395.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Donnelly, J.

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AU - Young, I.S.

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N2 - Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.

AB - Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.

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