Abstract
| Language | English |
|---|---|
| Title of host publication | Unknown Host Publication |
| Pages | 392-395 |
| Number of pages | 4 |
| Volume | 1019 |
| DOIs | |
| Publication status | Published - 2004 |
| Event | Unkown - Duration: 1 Jan 2004 → … |
Conference
| Conference | Unkown |
|---|---|
| Period | 1/01/04 → … |
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Keywords
- Aging
- Glutathione
- Glutathione peroxidase
- Malondialdehyde
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Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. / Rea, L.M.; McMaster, D.; Donnelly, J.; McGrath, L.T.; Young, I.S.
Unknown Host Publication. Vol. 1019 2004. p. 392-395.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study
AU - Rea, L.M.
AU - McMaster, D.
AU - Donnelly, J.
AU - McGrath, L.T.
AU - Young, I.S.
N1 - cited By 5
PY - 2004
Y1 - 2004
N2 - Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.
AB - Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.
KW - Aging
KW - Glutathione
KW - Glutathione peroxidase
KW - Malondialdehyde
U2 - 10.1196/annals.1297.070
DO - 10.1196/annals.1297.070
M3 - Conference contribution
VL - 1019
SP - 392
EP - 395
BT - Unknown Host Publication
ER -