Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study

L.M. Rea, D. McMaster, J. Donnelly, L.T. McGrath, I.S. Young

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Citations (Scopus)

Abstract

Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.
Original languageEnglish
Title of host publicationUnknown Host Publication
PublisherThe New York Academy of Sciences
Pages392-395
Number of pages4
Volume1019
DOIs
Publication statusPublished (in print/issue) - 2004
EventUnkown -
Duration: 1 Jan 2004 → …

Conference

ConferenceUnkown
Period1/01/04 → …

Bibliographical note

cited By 5

Keywords

  • Aging
  • Glutathione
  • Glutathione peroxidase
  • Malondialdehyde

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