Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study

L.M. Rea, D. McMaster, J. Donnelly, L.T. McGrath, I.S. Young

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    6 Citations (Scopus)

    Abstract

    Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.
    LanguageEnglish
    Title of host publicationUnknown Host Publication
    Pages392-395
    Number of pages4
    Volume1019
    DOIs
    Publication statusPublished - 2004
    EventUnkown -
    Duration: 1 Jan 2004 → …

    Conference

    ConferenceUnkown
    Period1/01/04 → …

    Fingerprint

    Malondialdehyde
    Antioxidants
    Glutathione
    Glutathione Peroxidase
    Lipid Peroxidation
    Free Radicals
    Survivors
    Oxidative Stress
    Age Groups
    Enzymes

    Keywords

    • Aging
    • Glutathione
    • Glutathione peroxidase
    • Malondialdehyde

    Cite this

    Rea, L. M., McMaster, D., Donnelly, J., McGrath, L. T., & Young, I. S. (2004). Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. In Unknown Host Publication (Vol. 1019, pp. 392-395) https://doi.org/10.1196/annals.1297.070
    Rea, L.M. ; McMaster, D. ; Donnelly, J. ; McGrath, L.T. ; Young, I.S. / Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. Unknown Host Publication. Vol. 1019 2004. pp. 392-395
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    abstract = "Glutathione and glutathione peroxidase activity are important components in the complex body defense against oxidative damage. In this study, we have measured malondialdehyde (MDA) as a marker of oxidative stress, the antioxidant glutathione (GSH), and activity of the antioxidant enzyme (GSHPx), in a cohort of free-living elderly subjects from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST), hypothesizing that free-living Senieur-approximated nonagenarians might demonstrate enhanced antioxidant defense mechanisms. The main finding in the BELFAST octo/ nonagenarians was that plasma antioxidant glutathione increased in nonagenarian compared with septo/octogenarian subjects (P = .015), whereas conversely antioxidant glutathione peroxidase activity fell in the nonagenarian group (P <.0001). In the same subject group, malondialdehyde, a measure of lipid peroxidation, showed no change across the age groups (P = .73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging.",
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    Rea, LM, McMaster, D, Donnelly, J, McGrath, LT & Young, IS 2004, Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. in Unknown Host Publication. vol. 1019, pp. 392-395, Unkown, 1/01/04. https://doi.org/10.1196/annals.1297.070

    Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. / Rea, L.M.; McMaster, D.; Donnelly, J.; McGrath, L.T.; Young, I.S.

    Unknown Host Publication. Vol. 1019 2004. p. 392-395.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

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    Rea LM, McMaster D, Donnelly J, McGrath LT, Young IS. Malondialdehyde and measures of antioxidant activity in subjects from the belfast elderly longitudinal free-living aging study. In Unknown Host Publication. Vol. 1019. 2004. p. 392-395 https://doi.org/10.1196/annals.1297.070