The ability of a magnetically responsive material to function as a carrier for photosensitizing agents for use in photoradiation therapy (PRT) has been examined in vitro. The photosensitizer has been attached to the magnetically responsive matrix (Dynabeads) by non-specific adsorption, Intralipid-mediated adsorption and poly-L-lysine mediated adsorption. In these studies, it has been demonstrated that conditions of attachment of photosensitizer to the matrix may be adapted in order to facilitate a diffuse or highly localized photo-toxic effect on target cells in vitro. The authors believe that this system may represent a novel approach to targeting photosensitizing agents to specific areas, thereby circumventing some of the problems associated with conventional photoradiation therapy (PRT), particularly in hollow organs.
FLYNN, G., HACKETT, TJ., MCHALE, L., & MCHALE, AP. (1994). MAGNETICALLY RESPONSIVE PHOTOSENSITIZING REAGENTS FOR POSSIBLE USE IN PHOTORADIATION THERAPY. Cancer Letters, 78(1-3), 109-114. https://doi.org/10.1016/0304-3835(94)90038-8