Magnetically Responsive Microbubbles as Delivery Vehicles for Targeted Sonodynamic and Antimetabolite Therapy of Pancreatic Cancer

Yinjie Sheng, Estelle Beguin, Heather Nesbitt, Sukanta Kamila, Joshua Owen, Lester Barnsley, Bridgeen Callan, Christopher O'Kane, Nikolitsa Nomikou, Rifat Hamoudi, Mark A Taylor, Mark Love, Paul Kelly, Declan O'Rourke, Eleanor Stride, AP McHale, J Callan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Magnetically responsive microbubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose Bengal (RB) and/or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreatic cancer using combined antimetabolite and sonodynamic therapy (SDT). MagMBs delivering the combined 5-FU/SDT treatment produced a reduction in cell viability of over 50% when tested against a panel of four pancreatic cancer cell lines in vitro. Intravenous administration of the MagMBs to mice bearing orthotopic human xenograft BxPC-3 tumours yielded a 48.3% reduction in tumour volume relative to an untreated control group (p
LanguageEnglish
Pages192-200
Number of pages9
JournalJournal of Controlled Release
Volume262
Early online date29 Jul 2017
DOIs
Publication statusPublished - 28 Sep 2017

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Antimetabolites
Microbubbles
Pancreatic Neoplasms
Fluorouracil
Rose Bengal
Therapeutics
Tumor Burden
Heterografts
Intravenous Administration
Phospholipids
Cell Survival
Gases
Oxygen
Cell Line
Control Groups
Neoplasms

Keywords

  • Microbubbles
  • magnetic targeting
  • drug delivery
  • hypoxia
  • 5-fluoruracil
  • Rose Bengal
  • sonodynamic therapy
  • antimetabolite therapy
  • pancreatic cancer.

Cite this

Sheng, Yinjie ; Beguin, Estelle ; Nesbitt, Heather ; Kamila, Sukanta ; Owen, Joshua ; Barnsley, Lester ; Callan, Bridgeen ; O'Kane, Christopher ; Nomikou, Nikolitsa ; Hamoudi, Rifat ; Taylor, Mark A ; Love, Mark ; Kelly, Paul ; O'Rourke, Declan ; Stride, Eleanor ; McHale, AP ; Callan, J. / Magnetically Responsive Microbubbles as Delivery Vehicles for Targeted Sonodynamic and Antimetabolite Therapy of Pancreatic Cancer. In: Journal of Controlled Release. 2017 ; Vol. 262. pp. 192-200.
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Magnetically Responsive Microbubbles as Delivery Vehicles for Targeted Sonodynamic and Antimetabolite Therapy of Pancreatic Cancer. / Sheng, Yinjie; Beguin, Estelle; Nesbitt, Heather; Kamila, Sukanta; Owen, Joshua; Barnsley, Lester; Callan, Bridgeen; O'Kane, Christopher; Nomikou, Nikolitsa; Hamoudi, Rifat; Taylor, Mark A; Love, Mark; Kelly, Paul; O'Rourke, Declan; Stride, Eleanor; McHale, AP; Callan, J.

In: Journal of Controlled Release, Vol. 262, 28.09.2017, p. 192-200.

Research output: Contribution to journalArticle

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AU - Sheng, Yinjie

AU - Beguin, Estelle

AU - Nesbitt, Heather

AU - Kamila, Sukanta

AU - Owen, Joshua

AU - Barnsley, Lester

AU - Callan, Bridgeen

AU - O'Kane, Christopher

AU - Nomikou, Nikolitsa

AU - Hamoudi, Rifat

AU - Taylor, Mark A

AU - Love, Mark

AU - Kelly, Paul

AU - O'Rourke, Declan

AU - Stride, Eleanor

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AU - Callan, J

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