Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

Opeolu Ojo, DK Srinivasan, BO Owolabi, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P
LanguageEnglish
Pages80-87
JournalBiochim Biophys Acta
Volume1850
Issue number1
DOIs
Publication statusPublished - 20 Oct 2014

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Magainins
Homeostasis
Fats
Glucose
Insulin
Peptides
Glucagon-Like Peptide 1
Glucose Intolerance
National Institutes of Health (U.S.)
High Fat Diet
Amphibians
Blood Glucose
Obesity
Eating
Body Weight
Diet

Cite this

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abstract = "AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P",
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Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice. / Ojo, Opeolu; Srinivasan, DK; Owolabi, BO; Conlon, JM; Flatt, Peter; Abdel-Wahab, Yasser.

Vol. 1850, No. 1, 20.10.2014, p. 80-87.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

AU - Ojo, Opeolu

AU - Srinivasan, DK

AU - Owolabi, BO

AU - Conlon, JM

AU - Flatt, Peter

AU - Abdel-Wahab, Yasser

PY - 2014/10/20

Y1 - 2014/10/20

N2 - AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

AB - AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

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