Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

Opeolu Ojo; DK Srinivasan; BO Owolabi; JM Conlon; Peter Flatt; Yasser Abdel-Wahab

doi:10.1016/j.bbagen.2014.10.011

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

Opeolu Ojo, DK Srinivasan, BO Owolabi, JM Conlon, Peter Flatt, Yasser Abdel-Wahab

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

Original language	English
Pages (from-to)	80-87
Journal	Biochim Biophys Acta
Volume	1850
Issue number	1
DOIs	https://doi.org/10.1016/j.bbagen.2014.10.011
Publication status	Published (in print/issue) - 20 Oct 2014

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abstract = "AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P",

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T1 - Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

AU - Ojo, Opeolu

AU - Srinivasan, DK

AU - Owolabi, BO

AU - Conlon, JM

AU - Flatt, Peter

AU - Abdel-Wahab, Yasser

PY - 2014/10/20

Y1 - 2014/10/20

N2 - AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

AB - AbstractBACKGROUND: Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.METHODS: Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.RESULTS: Following twice daily treatment with magainin-AM2 for 15days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

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Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice.

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